Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

996 questions · 1,049 findings · 79 reviews · Dementia and Cognitive Improvement

No studies found 240 · 22.9%GRADE not reported 31 · 3%Very low 216 · 20.6%Low 253 · 24.1%Moderate 238 · 22.7%High 71 · 6.8%

Older adults with anticholinergic burden vs older adults with no anticholinergic burden

Cognitive decline or dementia · older adults without cognitive impairment at baseline

Older adults with anticholinergic burden may leads to higher cognitive decline or dementia compared with older adults with no anticholinergic burden (low certainty).

1 finding from 1 review

Multi‐domain interventions vs placebo or usual care

Cognitive decline · Older people living in the community
3 findings from 1 review