Cochrane · systematic review · CD013540
Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome
Taylor-Rowan, M, Edwards, S, Noel-Storr, AH, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
1
current version
GRADE rated
1
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Older adults with anticholinergic burden compared with older adults with no anticholinergic burden for dementia
Population: older adults without cognitive impairment at baseline
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognitive decline or dementia Older adults with anticholinergic burden vs older adults with no anticholinergic burden | OR 2.63 [1.09, 6.29] | 4 studies · 125359 participants | Low Downgraded: risk of bias, imprecision, publication bias |