Cochrane · systematic review · CD013572
Multi‐domain interventions for the prevention of dementia and cognitive decline
Hafdi, M, Hoevenaar-Blom, MP, Richard, E · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 0 · 0%Moderate 2 · 33.3%High 3 · 50%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Multi‐domain interventions compared to usual care/placebo for the prevention of dementia and cognitive decline
Population: community‐dwelling older adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of dementia Multi‐domain interventions vs usual care/placebo | RR 0.94 [0.76, 1.18] | 2 studies · 7256 participants | High |
Incidence of MCI Multi‐domain interventions vs usual care/placebo | RR 0.97 [0.76, 1.23] | 1 study · 3802 participants | Moderate Downgraded: imprecision |
Cognitive decline Multi‐domain interventions vs usual care/placebo | no estimate extracted | 3 studies · 4617 participants | High |
Cognitive decline Multi‐domain interventions vs usual care/placebo | no estimate extracted | 6 studies · 8697 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Cognitive decline Multi‐domain interventions vs usual care/placebo | no estimate extracted | 2 studies · 1554 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Mortality Multi‐domain interventions vs usual care/placebo | RR 0.93 [0.84, 1.04] | 4 studies · 11487 participants | High |