What do systematic reviews say?

Brief co‐incubation vs standard insemination

Brief co‐incubation showed no clear difference in miscarriage rate per randomized woman compared with standard insemination (low certainty).

• Brief co‐incubation of sperm and oocytes for in vitro fertilization techniques 2013 · Cochrane Headline outcomes only
  OR 1.98 [0.35, 11.09]
  1 study · 167 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes live birth rate per woman (very low certainty).

• Heparin for assisted reproduction 2013 · Cochrane Headline outcomes only
  OR 1.77 [1.07, 2.9]
  3 studies · 386 participants
  Very low

Intervention not reported

The intervention may leads to higher clinical pregnancy rate per woman (low certainty).

• Heparin for assisted reproduction 2013 · Cochrane Headline outcomes only
  OR 1.61 [1.03, 2.53]
  3 studies · 386 participants
  Low

Intervention not reported

• Heparin for assisted reproduction 2013 · Cochrane Headline outcomes only
  no estimate extracted
  5 participants
  GRADE not reported

Intervention not reported

It is very uncertain whether the intervention changes live birth rate per woman (very low certainty).

• Heparin for assisted reproduction 2013 · Cochrane Headline outcomes only
  OR 1.85 [0.8, 4.24]
  3 studies · 386 participants
  Very low

Intervention not reported

The intervention showed no clear difference in clinical pregnancy rate per woman (low certainty).

• Heparin for assisted reproduction 2013 · Cochrane Headline outcomes only
  OR 1.66 [0.94, 2.9]
  3 studies · 386 participants
  Low

Intervention not reported

• Heparin for assisted reproduction 2013 · Cochrane Headline outcomes only
  no estimate extracted
  5 participants
  GRADE not reported

Low‐dose hCG vs FSH throughout the COH

It is very uncertain whether low‐dose hCG changes live birth compared with FSH throughout the COH (very low certainty).

• FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques 2013 · Cochrane Headline outcomes only
  RR 1.56 [0.75, 3.25]
  2 studies · 130 participants
  Very low

Low‐dose hCG vs FSH throughout the COH

It is very uncertain whether low‐dose hCG changes OHSS compared with FSH throughout the COH (very low certainty).

• FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques 2013 · Cochrane Headline outcomes only
  OR 0.3 [0.06, 1.59]
  5 studies · 351 participants
  Very low

Low‐dose hCG vs FSH throughout the COH

Low‐dose hCG showed no clear difference in ongoing pregnancy compared with FSH throughout the COH (low certainty).

• FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques 2013 · Cochrane Headline outcomes only
  RR 1.17 [0.83, 1.64]
  3 studies · 252 participants
  Low

Low‐dose hCG vs FSH throughout the COH

Low‐dose hCG showed no clear difference in clinical pregnancy compared with FSH throughout the COH (low certainty).

• FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques 2013 · Cochrane Headline outcomes only
  RR 1.19 [0.92, 1.55]
  5 studies · 351 participants
  Low

Low‐dose hCG vs FSH throughout the COH

It is very uncertain whether low‐dose hCG changes miscarriage compared with FSH throughout the COH (very low certainty).

• FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques 2013 · Cochrane Headline outcomes only
  RR 1.08 [0.5, 2.31]
  4 studies · 127 participants
  Very low

Low‐dose hCG vs FSH throughout the COH

• FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques 2013 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 333 participants
  Moderate

Low‐dose hCG vs FSH throughout the COH

• FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques 2013 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 333 participants
  Moderate

GnRH analogues vs placebo or no treatment

It is very uncertain whether gnRH analogues changes postoperative amenorrhoea at 12 months or less compared with placebo or no treatment (very low certainty).

• Pre‐operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding 2013 · Cochrane Headline outcomes only
  RR 1.58 [1.24, 2.01]
  605 participants
  Very low

GnRH analogues vs danazol

It is very uncertain whether gnRH analogues changes postoperative amenorrhoea at 12 months or less compared with danazol (very low certainty).

• Pre‐operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding 2013 · Cochrane Headline outcomes only
  RR 1.17 [0.9, 1.52]
  340 participants
  Very low

GnRH analogues vs Progestogen 2

It is very uncertain whether gnRH analogues changes postoperative amenorrhoea at 12 months or less compared with progestogens (very low certainty).

• Pre‐operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding 2013 · Cochrane Headline outcomes only
  RR 1.58 [0.96, 2.61]
  146 participants
  Very low

GnRH analogues vs GnRH antagonists

GnRH analogue showed no clear difference in postoperative amenorrhoea at 12 months or less compared with gnRH antagonist (moderate certainty).

• Pre‐operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding 2013 · Cochrane Headline outcomes only
  RR 0.95 [0.79, 1.14]
  100 participants
  Moderate

GnRH analogues vs dilatation & curettage

It is very uncertain whether gnRH analogue changes postoperative amenorrhoea at 12 months or less compared with dilatation & curettage (very low certainty).

• Pre‐operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding 2013 · Cochrane Headline outcomes only
  RR 20.12 [1.21, 333.63]
  92 participants
  Very low

Danazol vs no pretreatment

Danazol showed no clear difference in postoperative amenorrhoea at 12 months or less compared with no pretreatment (low certainty).

• Pre‐operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding 2013 · Cochrane Headline outcomes only
  RR 1.05 [0.8, 1.39]
  179 participants
  Low