Cochrane · systematic review · CD010241
Pre‐operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding
Tan, YH, Lethaby, A · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 44.4%Low 4 · 44.4%Moderate 1 · 11.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
GnRH analogues compared with placebo or no treatment for heavy menstrual bleeding
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative amenorrhoea at 12 months or less GnRH analogues vs placebo or no treatment | RR 1.58 [1.24, 2.01] | 605 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
GnRH analogues compared with danazol for heavy menstrual bleeding
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative amenorrhoea at 12 months or less GnRH analogues vs danazol | RR 1.17 [0.9, 1.52] | 340 participants | Very low Downgraded: risk of bias, inconsistency |
GnRH analogues compared with progestogens for heavy menstrual bleeding
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative amenorrhoea at 12 months or less GnRH analogues vs progestogens | RR 1.58 [0.96, 2.61] | 146 participants | Very low Downgraded: risk of bias, imprecision |
GnRH analogue compared with GnRH antagonist for heavy menstrual bleeding
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative amenorrhoea at 12 months or less GnRH analogue vs GnRH antagonist | RR 0.95 [0.79, 1.14] | 100 participants | Moderate |
GnRH analogue compared with dilatation & curettage for heavy menstrual bleeding
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative amenorrhoea at 12 months or less GnRH analogue vs dilatation & curettage | RR 20.12 [1.21, 333.63] | 92 participants | Very low Downgraded: risk of bias, imprecision |
Danazol compared with no pretreatment for heavy menstrual bleeding
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative amenorrhoea at 12 months or less Danazol vs no pretreatment | RR 1.05 [0.8, 1.39] | 179 participants | Low Downgraded: risk of bias |
Progestogens compared with no pretreatment for heavy menstrual bleeding
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative amenorrhoea at 12 months or less Progestogens vs no pretreatment | RR 0.54 [0.26, 1.12] | 50 participants | Low Downgraded: risk of bias |
Danazol compared with progestogens for heavy menstrual bleeding
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative amenorrhoea at 12 months or less Danazol vs progestogens | RR 1.89 [1.12, 3.18] | 103 participants | Low Downgraded: risk of bias |
GnRHa or danazol compared with no pretreatment for heavy menstrual bleeding
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative amenorrhoea at 12 months or less GnRHa or danazol vs no pretreatment | RR 1.13 [0.89, 1.43] | 280 participants | Low Downgraded: risk of bias |