Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Pneumothorax · Preterm infants for prevention of RDS

Bovine lung lavage surfactant extract showed no clear difference in pneumothorax. compared with modified bovine minced lung surfactant extract (moderate certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Pulmonary hemorrhage · Preterm infants for prevention of RDS

Bovine lung lavage surfactant extract showed no clear difference in pulmonary hemorrhage compared with modified bovine minced lung surfactant extract (low certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Severe intraventricular hemorrhage in infants who received neuroimaging · Preterm infants for prevention of RDS

Bovine lung lavage surfactant extract showed no clear difference in severe IVH in infants receiving neuroimaging compared with modified bovine minced lung surfactant extract (low certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Mortality before hospital discharge · Preterm infants for treatment of RDS

Bovine lung lavage surfactant extract showed no clear difference in mortality prior to discharge compared with modified bovine minced lung surfactant extract (moderate certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Oxygen requirement at 36 weeks' postmenstrual age · Preterm infants for treatment of RDS

Bovine lung lavage surfactant extract showed no clear difference in oxygen requirement at 36 weeks' postmenstrual age (all infants) compared with modified bovine minced lung surfactant extract (high certainty).

1 finding from 1 review

Intervention not reported

CRBSI (confirmed) Clinical and microbiological assessments · newborn infants who require a central venous catheter

The intervention leads to lower CRBSI (confirmed) Clinical and microbiological assessments (high certainty).

1 finding from 1 review

Intervention not reported

CRBSI (suspected) Clinical assessment · newborn infants who require a central venous catheter

The intervention showed no clear difference in CRBSI (suspected) Clinical assessment (moderate certainty).

1 finding from 1 review

Intervention not reported

Total CRBSI (confirmed and suspected) Clinical and microbiological assessments · newborn infants who require a central venous catheter

The intervention leads to lower total CRBSI (confirmed and suspected) Clinical and microbiological… (high certainty).

1 finding from 1 review

Intervention not reported

Mortality Clinical assessment · newborn infants who require a central venous catheter

It is very uncertain whether the intervention changes mortality Clinical assessment (very low certainty).

1 finding from 1 review

Intervention not reported

Number of infants with hypoglycaemia Blood sugar level: glucose meter or laboratory‐based plasma glucose level · newborn infants who require a central venous catheter

The intervention leads to lower number of infants with hypoglycaemia Blood sugar level: glucose… (high certainty).

1 finding from 1 review

Adjunctive steroid vs placebo

Hearing loss · neonates with clinical and microbiological features of bacterial meningitis

Adjunctive steroid showed no clear difference in hearing loss at 2 years of age compared with placebo (low certainty).

2 findings from 1 review