Intervention not reported
Calcific metamorphosis (adverse event)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Adverse effects · People with avulsed and replanted permanent (front) teeth
1 finding from 1 review
Soft tissue pathology · Children with carious vital pulp exposure in primary incisors
No statistically significant difference in soft tissue pathology between pulpotomy and pulpectomy (RR 3.11, 95% CI 0.54 to 17.7; ungraded).
1 finding from 1 review
RR 3.11 [0.54, 17.7]
Studies not reported
GRADE not reported
Pathological mobility · Children with carious vital pulp exposure in primary incisors
Pathological mobility was rare (one tooth in one of four trials) and was not pooled.
1 finding from 1 review
Patient-reported pain intensity (sum of pain intensity difference (SPID) and sum of pain percussion intensity difference (SPPID)) · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis
1 finding from 1 review
Corresponding risk (Antibiotics): The in between-group differences (median +/- IQR) in SPID for the penicillin group were 6.0 +/- 10.5, and for placebo 6.0 +/- 9.5. The SPPID for the penicillin group was 3.5 +/- 7.5…
1 study · 40 participants
Low
Adverse effects · People with avulsed and replanted permanent (front) teeth
1 finding from 1 review
Pathological root resorption · Children with carious vital pulp exposure in primary incisors
No statistically significant difference in pathological root resorption between pulpotomy and pulpectomy (RR 1.5, 95% CI 0.56 to 4.04; ungraded).
1 finding from 1 review
RR 1.5 [0.56, 4.04]
2 studies
GRADE not reported
Tooth survival · People with avulsed and replanted permanent (front) teeth
1 finding from 1 review
Tooth survival at 12 months: Not estimable (due to no events in either arm); 27 teeth in 22 patients (1 RCT). At 12 months, no teeth were lost. 1 tooth was lost at 16 months in the Ultracal group.
1 study · 22 participants
Very low
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single RCT found higher pulpotomy success with MTA than abscess remedy (100% vs 80%; statistically significant, P<0.05; not pooled; ungraded).
1 finding from 1 review
Single RCT (Eppa 2018, 3-arm; 20 MTA and 20 AR teeth): MTA 100% (20/20) vs abscess remedy 80% (16/20) clinical and radiographic success; the 4 abscess-remedy failures occurred at 3 months; difference statistically…
1 study · 40 participants
GRADE not reported
Radiographic failure · Children with carious vital pulp exposure in primary incisors
No statistically significant difference in radiographic failure between pulpotomy and pulpectomy in the main analysis (RR 0.79, 95% CI 0.25 to 2.42), with considerable heterogeneity (I2=76%; ungraded).
2 findings from 1 review
Total number of paracetamol (acetaminophen) with codeine (Tylenol) tablets · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis
Systemic antibiotic (oral penicillin 500 mg) plus analgesic showed no clear difference in total number of paracetamol (acetaminophen) with codeine (Tylenol)… compared with placebo plus analgesic (low certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single 3-arm RCT found no difference in pulpotomy success between MTA and triple antibiotic paste (both 100%; not pooled; ungraded).
1 finding from 1 review
Single RCT (Eppa 2018, 3-arm; 20 MTA and 20 TAP teeth): 100% clinical and radiographic success in both MTA and TAP at all follow-ups (1-24 months); no difference between groups; not pooled
1 study · 40 participants
GRADE not reported
Storage of the tooth prior to replantation (storage medium) vs Different storage medium or dry storage
Outcome not reported · People with avulsed and replanted permanent (front) teeth
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Intervention not reported
Marginal restoration discoloration (adverse event)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Radiographic resorption (proxy measure for periodontal healing) at 12 months · People with avulsed and replanted permanent (front) teeth
It is very uncertain whether extra-oral pulp extirpation at day 0 changes radiographic resorption (proxy measure for periodontal healing) at… compared with intra-oral pulp extirpation at day 7 (very low certainty).
1 finding from 1 review
Pain · Children with carious vital pulp exposure in primary incisors
No statistically significant difference in pain between pulpotomy and pulpectomy (RR 2.06, 95% CI 0.31 to 13.8; ungraded).
1 finding from 1 review
RR 2.06 [0.31, 13.8]
Studies not reported
GRADE not reported
Pulpal healing at 12 months · People with avulsed and replanted permanent (front) teeth
It is very uncertain whether hyperbaric oxygen (following replantation) changes pulpal healing at 12 months compared with control (very low certainty).
1 finding from 1 review
Pulp canal obliteration · Children with carious vital pulp exposure in primary incisors
Pulp canal obliteration was reported narratively (mainly in the pulpotomy group) and was not pooled.
1 finding from 1 review
Intervention not reported
Clinical and radiographic success
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Periodontal healing at 12 months · People with avulsed and replanted permanent (front) teeth
It is very uncertain whether hyperbaric oxygen (following replantation) changes periodontal healing at 12 months compared with control (very low certainty).
1 finding from 1 review