What do systematic reviews say?

Perampanel add‐on vs placebo

Perampanel add‐on may leads to higher treatment withdrawal due to adverse effects compared with placebo (low certainty).

• Perampanel add‐on for drug‐resistant focal epilepsy 2023 · Cochrane Headline outcomes only
  RR 2.36 [1.59, 3.51]
  7 studies · 2524 participants
  Low

Pregabalin vs placebo

Pregabalin probably leads to higher treatment withdrawal due to adverse effects compared with placebo (moderate certainty).

• Pregabalin add‐on for drug‐resistant focal epilepsy 2022 · Cochrane Headline outcomes only
  RR 2.6 [1.86, 3.64]
  9 studies · 2663 participants
  Moderate

Benzoyl peroxide vs salicylic acid

• Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 59 participants
  Very low

Benzoyl peroxide vs erythromycin

It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (medium‐term data) Treatment… compared with erythromycin (very low certainty).

• Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
  RR 1 [0.07, 15.26]
  1 study · 60 participants
  Very low

Benzoyl peroxide vs placebo or no treatment

Benzoyl peroxide may leads to higher withdrawal due to adverse effects (long‐term data) Treatment… compared with placebo or no treatment (low certainty).

• Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
  RR 2.13 [1.55, 2.93]
  24 studies · 13744 participants
  Low

Benzoyl peroxide vs adapalene

It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (long‐term data) Treatment… compared with adapalene (very low certainty).

• Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
  RR 1.85 [0.94, 3.64]
  11 studies · 3295 participants
  Very low

Benzoyl peroxide vs clindamycin

It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (long‐term data) Treatment… compared with clindamycin (very low certainty).

• Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
  RR 1.93 [0.9, 4.11]
  8 studies · 3330 participants
  Very low

Calcium channel blockers vs placebo

Calcium channel blockers showed no clear difference in number of withdrawals due to adverse events Number of participants… compared with placebo (low certainty).

• Calcium channel blockers for primary and secondary Raynaud's phenomenon 2017 · Cochrane Headline outcomes only
  RR 1.3 [0.51, 3.33]
  2 studies · 63 participants
  Low