Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

17 questions · 17 findings · 7 reviews · Stroke

No studies found 2 · 11.8%GRADE not reported 0 · 0%Very low 6 · 35.3%Low 4 · 23.5%Moderate 2 · 11.8%High 3 · 17.6%

TDC vs medical therapy

Recurrent events: fatal or non‐fatal (same type of stroke, i.e. ischaemic or haemorrhagic) · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in primary outcome measure: recurrent stroke (non‐fatal or fatal) compared with medical therapy (low certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Long‐term ipsilateral stroke · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes ipsilateral stroke (fatal or non‐fatal; haemorrhage or infarct)… compared with primary closure (very low certainty).

1 finding from 1 review

Marine‐derived n‐3 fatty acids therapy vs No marine‐derived n‐3 fatty acids therapy

Recurrent events: fatal or non‐fatal (same type of stroke, i.e. ischaemic or haemorrhagic) · stroke and/or TIA

It is very uncertain whether marine‐derived n‐3 fatty acids therapy changes recurrent events: fatal or non‐fatal (same type of stroke, i.e.… compared with no marine‐derived n‐3 fatty acids therapy (very low certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Perioperative ipsilateral stroke (< 30 days) · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes ipsilateral stroke (fatal or non‐fatal; haemorrhage or infarct)… compared with primary closure (very low certainty).

1 finding from 1 review

TDC vs medical therapy

Primary outcome measure: composite of recurrent stroke (non‐fatal or fatal) or transient ischemic attack (TIA) · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in primary outcome measure: composite of recurrent stroke (non‐fatal or… compared with medical therapy (low certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Long‐term any stroke · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes any stroke (fatal or non‐fatal; contralateral, ipsilateral or… compared with primary closure (very low certainty).

1 finding from 1 review

Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment

Stroke, myocardial infarction, or vascular death · stroke and/or TIA

Blood pressure‐lowering drugs (BPLDs) showed no clear difference in major vascular event (composite of non‐fatal stroke, non‐fatal… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Stroke · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes any stroke (fatal or non‐fatal; contralateral, ipsilateral or… compared with primary closure (very low certainty).

1 finding from 1 review

TDC vs medical therapy

Primary outcome measure: recurrent stroke (non‐fatal or fatal) stratified by the type of device studied ‐ Amplatzer PFO occluder · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in primary outcome measure: recurrent stroke (non‐fatal or fatal)… compared with medical therapy (low certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs medical treatment

Fatal/non‐fatal stroke in the territory of the treated vertebral artery stenosis(assessed after 30 days post‐randomisation to completion of · people with vertebral artery stenosis

Endovascular treat ment plus medical treatment showed no clear difference in fatal/non‐fatal stroke in the territory of the treated vertebral… compared with medical treatment alone (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of patients with all vascular events (stroke, MI, non‐fatal cardiac arrest, unstable angina requiring revascularisation, vascular death) at 90 days and at 1 year · patients with TIA or ischaemic stroke

The review found no eligible studies for this question.

1 finding from 1 review

TDC vs medical therapy

Primary outcome measure: composite of recurrent stroke (non‐fatal or fatal) or transient ischemic attack (TIA) stratified by the type of device ‐ Amplatzer PFO occluder · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in primary outcome measure: composite of recurrent stroke (non‐fatal or… compared with medical therapy (low certainty).

1 finding from 1 review