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What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 9 findings · 3 reviews · Musculoskeletal

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No studies found 2 · 22.2%GRADE not reported 2 · 22.2%Very low 2 · 22.2%Low 3 · 33.3%Moderate 0 · 0%High 0 · 0%

Tramadol vs paracetamol

Number of participants experiencing any serious adverse events · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol vs NSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants experiencing any serious adverse events compared with NSAIDs (very low certainty).

1 finding from 1 review

Tramadol vs other opioids

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants experiencing any serious adverse events compared with other opioids (very low certainty).

1 finding from 1 review

Tramadol vs placebo

Number of participants experiencing any serious adverse events · Patients with osteoarthritis of the knee or hip

Tramadol alone may leads to higher number of participants experiencing any serious adverse events compared with placebo (low certainty).

1 finding from 1 review