What do systematic reviews say?

Silver diamine fluoride (SDF, including SDF + fluoride varnish) vs Other standard-of-care caries treatments pooled (placebo, ART, or ART + fluoride varnish)

SDF had no significant effect on oral health-related quality of life versus pooled standard-of-care caries treatments (SMD -0.06, 95% CI -0.20 to 0.08; ungraded).

• Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis. 2022 All outcomes

  Post-treatment (follow-up varied by trial) · Pediatric dental care; trials conducted in China, the USA, and Brazil
  SMD -0.06 [-0.20, 0.08]
  5 studies · 820 participants
  GRADE not reported

Postnatal pelvic floor muscle training vs control

• Pelvic floor muscle training for preventing and treating urinary and faecal incontinence in antenatal and postnatal… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 170 participants
  GRADE not reported

Intervention not reported

• Braces and orthoses for treating osteoarthritis of the knee 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 179 participants
  Moderate

Exercise vs no treatment

It is very uncertain whether physical exercise changes quality of life VEINES‐QOL/SF‐36/CIVIQ‐20 (lower is better) compared with no treatment (very low certainty).

• Physical exercise for the treatment of non‐ulcerated chronic venous insufficiency 2023 · Cochrane Headline outcomes only
  MD 4.6
  2 studies · 61 participants
  Very low

Any pessary vs pelvic floor muscle training (PFMT)

• Pessaries (mechanical devices) for managing pelvic organ prolapse in women 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 116 participants
  Low

Intervention not reported

The intervention showed no clear difference in health‐related quality of life (HRQOL) disease‐specific HRQOL (low certainty).

• Positive expiratory pressure therapy versus other airway clearance techniques for bronchiectasis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  17 participants
  Low

Salicylic acid vs tretinoin

• Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Very low

Smartphone app vs no intervention or minimal intervention

• Mobile health (m‐health) smartphone interventions for adolescents and adults with overweight or obesity 2024 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 149 participants
  Moderate

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Spironolactone 100 mg vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Finasteride 5 mg to 7.5 mg vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin 500 mg to 2550 mg per day vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Finasteride 5 mg vs spironolactone 100 mg

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Flutamide 250 mg once to b.i.d. vs metformin 1275 mg to 1700 mg per day

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Finasteride 5 mg vs flutamide 250 mg once to b.i.d.

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Flutamide 250 mg b.i.d. vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

CBT vs ALL OTHER PSYCHOLOGICAL THERAPIES

• Cognitive behavioural therapy plus standard care versus standard care plus other psychosocial treatments for people… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 64 participants
  Very low

Mobile stroke team vs general medical ward

• Organised inpatient (stroke unit) care for stroke: network meta‐analysis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 308 participants
  Very low

Acupuncture vs sham

• Acupuncture for chronic nonspecific low back pain 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1068 participants
  Low