What do systematic reviews say?

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after submucosal instrumentation (SI) vs Submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT

The review found no eligible studies for this question.

• Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes
  Only one study reported evidence for adjunctive aPDT in people with peri-implant disease (Al Rifaiy 2022). Data were only available for two outcomes (PPD and BOP), both reported only at three months. No studies…
  Studies not reported
  No studies found

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

The review found no eligible studies for this question.

• Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes
  No studies reported data for this outcome.
  Studies not reported
  No studies found

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

The review found no eligible studies for this question.

• Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
  The trials did not measure quality of life.
  0 studies
  No studies found

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

The review found no eligible studies for this question.

• Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes
  No studies reported data for this outcome.
  Studies not reported
  No studies found

Intervention not reported

• Strategies to integrate oral health into primary care: a systematic review. 2023 All outcomes
  1 study reported an unfavourable outcome
  1 study
  GRADE not reported

CBT vs alternative treatment

The review found no eligible studies for this question.

• Psychological therapies for temporomandibular disorders (TMDs) 2022 · Cochrane All outcomes
  This outcome was not measured (not synthesised for this comparison; review-wide only one study reported quality of life).
  Studies not reported
  No studies found

CBT vs inactive control (usual care care, attention control, waitlist)

The review found no eligible studies for this question.

• Psychological therapies for temporomandibular disorders (TMDs) 2022 · Cochrane All outcomes
  This outcome was not measured for this comparison.
  Studies not reported
  No studies found

Hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy vs conventional therapy

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  6 months
  QoL measured with the Duke Health Profile; only within-group comparisons were provided; no score values, so a between-group analysis was not possible.
  1 study
  GRADE not reported

Chemotherapy (any regimen; added to, or compared with, locoregional treatment) vs Locoregional treatment and/or an alternative chemotherapy regimen

The review found no eligible studies for this question.

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  Quality of life was a planned (protocol) outcome but no included trial provided usable quality-of-life data; the protocol was modified to report only survival/response outcomes.
  0 studies
  No studies found

Any orthodontic (non-surgical) treatment to correct posterior crossbite or expand the top teeth vs No treatment or another orthodontic treatment

The review found no eligible studies for this question.

• Orthodontic treatment for posterior crossbites 2021 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning

The review found no eligible studies for this question.

• Interventions for managing halitosis 2019 · Cochrane All outcomes
  Quality of life was a prespecified secondary outcome. None of the 44 included studies in the review (across all comparisons) reported quality-of-life data (review-wide evidence gap).
  0 studies
  No studies found

Orthodontic treatment without extraction of permanent teeth vs Orthodontic treatment involving extraction of permanent teeth

The review found no eligible studies for this question.

• Orthodontic treatment for deep bite and retroclined upper front teeth in children 2018 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Orthodontic treatment without extraction of permanent teeth vs No treatment (or delayed treatment)

The review found no eligible studies for this question.

• Orthodontic treatment for deep bite and retroclined upper front teeth in children 2018 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Amifostine vs no treatment/placebo

Amifostine showed no clear difference in quality of life compared with no treatment/placebo; GRADE not reported.

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  End of RT; up to 3 months postRT
  MD 0.52 [-0.02, 1.06]
  1 study · 233 participants
  GRADE not reported

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

The review found no eligible studies for this question.

• Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
  No studies reported this outcome (planned secondary outcome not measured by any study in the review)
  0 studies
  No studies found

Antiseptic mouthrinse vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  No quality of life data were reported.
  0 studies
  No studies found

Bethanechol vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  No data on either quality of life or other oral related symptoms were reported.
  0 studies
  No studies found

Chinese medicine vs no treatment/placebo

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  End of intervention to 3 months postRT
  Insufficient evidence to determine any effect on quality of life (Lin 2014; Analysis 6.5)
  1 study
  GRADE not reported

Amifostine (intravenous) vs Amifostine (subcutaneous)

The review found no eligible studies for this question.

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  No data on either quality of life or other oral related symptoms were reported.
  0 studies
  No studies found

Venalot Depot (coumarin plus troxerutin) vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  No data on either quality of life or other oral related symptoms were reported.
  0 studies
  No studies found