What do systematic reviews say?

Intervention not reported

• Strategies to integrate oral health into primary care: a systematic review. 2023 All outcomes
  1 study reported an unfavourable outcome
  1 study
  GRADE not reported

Chemotherapy (any regimen; added to, or compared with, locoregional treatment) vs Locoregional treatment and/or an alternative chemotherapy regimen

The review found no eligible studies for this question.

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  Quality of life was a planned (protocol) outcome but no included trial provided usable quality-of-life data; the protocol was modified to report only survival/response outcomes.
  0 studies
  No studies found

Interdental brushing plus toothbrushing vs Toothbrushing alone

The review found no eligible studies for this question.

• Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
  Not estimable. No included study assessed quality of life as an outcome. (See comment)
  0 studies
  No studies found

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

The review found no eligible studies for this question.

• Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
  Not estimable. No included study assessed quality of life as an outcome. (See comment)
  0 studies
  No studies found

Flossing plus toothbrushing (self-performed; manual or automated floss) vs Toothbrushing alone

The review found no eligible studies for this question.

• Flossing for the management of periodontal diseases and dental caries in adults 2011 · Cochrane All outcomes
  Not estimable (0 studies). See comment: No included study assessed quality of life as an outcome.
  0 studies
  No studies found

Radiotherapy (morning) vs Afternoon radiotherapy

• Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy 2010 · Cochrane All outcomes
  Bjarnason 2009: no statistically significant difference in quality of life scores (data not reported). Morning radiotherapy was associated with significantly less weight loss after 5 months.
  1 study · 216 participants
  GRADE not reported

Toothache vs No toothache

The umbrella review reported that toothache has a high impact on oral health-related quality of life.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Dental (tooth) agenesis vs No dental agenesis

The umbrella review reported insufficient scientific evidence to support an association between dental agenesis and oral health-related quality of life.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  tooth agenesis does not have enough scientific evidence to support a relationship between OHRQoL [41]. No articles were found that had evaluated children and adolescent. Only one was found to have a greater impact in…
  Studies not reported
  GRADE not reported

Malocclusion vs No malocclusion

The umbrella review reported that malocclusion negatively affects oral health-related quality of life.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Periodontal disease (severe periodontitis) vs No or less severe periodontal disease

The umbrella review reported worse oral health-related quality-of-life scores with severe periodontitis.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Dental caries or greater caries severity vs No or less severe dental caries

The umbrella review reported worse oral health-related quality of life with greater caries severity.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral health promotion program

Oral health promotion programs have a positive effect on OHRQoL in adolescents (narrative synthesis; low methodological quality of included evidence; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  It was observed that health promotion programs have a positive effect on OHRQoL. Studies showed positive effects of OHPP on adolescentes OHRQoL with low methodological quality [38].
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Completed orthodontic treatment vs No previous or incomplete orthodontic treatment

The umbrella review reported better oral health-related quality of life after completed orthodontic treatment.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Older age vs Younger adults (population mean age <=33.4 years)

The abstract reports older age is associated with worse OHRQoL, but the body notes the evidence on age is limited and conflicting (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  Worse oral health status, older age, female sex and worse socioeconomic status were significantly associated with worse OHRQoL. [Body: the influence of religion and age on OHRQoL is unknown; Biological data such as…
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Female sex vs Male sex

The abstract reports female sex is associated with worse OHRQoL, but the conclusion states the impact of gender was not clarified (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  Worse oral health status, older age, female sex and worse socioeconomic status were significantly associated with worse OHRQoL. [Conclusion: gender and skin color did not have their level of impact clarified.]
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Bruxism vs No bruxism

Bruxism was not shown to impact OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  While dental erosion and bruxism have not been shown to impact the quality of life of adolescents [26]. Bruxism does not impact quality of life in children and adolescentes [33].
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Dental erosion vs No dental erosion

The umbrella review reported that dental erosion has not been shown to affect oral health-related quality of life.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  While dental erosion and bruxism have not been shown to impact the quality of life of adolescents [26].
  Studies not reported
  GRADE not reported

Favorable socioeconomic and family environment vs Less favorable socioeconomic and family environment

The umbrella review reported better oral health-related quality of life with favorable housing, parental education, income, family environment, and access to dental care.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Temporomandibular disorder vs No temporomandibular disorder

Temporomandibular disorder is associated with worse OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  dental caries, malocclusion [9, 26-30], TMD [9], dental trauma (TDI) [32, 34, 35], poor brushing [36], toothache [26], periodontal disease [34] and edentulism [9] negatively affect the quality of life of adolescents.
  Studies not reported
  GRADE not reported
• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported

Irregular brushing vs Regular brushing

The umbrella review reported that irregular brushing negatively affects oral health-related quality of life.

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
  no estimate extracted
  Studies not reported
  GRADE not reported