What do systematic reviews say?

Anti‐VEGF vs control

Summary of findings: anti‐VEGF treatment probably leads to higher mean change in vision‐related quality of life compared with control (moderate certainty).

• Anti‐vascular endothelial growth factor for neovascular age‐related macular degeneration 2019 · Cochrane Headline outcomes only
  MD 6.69 [3.38, 9.99]
  2 studies · 1134 participants
  Moderate

Dinutuximab‐containing immunotherapy vs usual care

The review found no eligible studies for this question.

• Anti‐GD2 antibody‐containing immunotherapy postconsolidation therapy for people with high‐risk neuroblastoma treated… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Methotrexate vs other DMARDs

The review found no eligible studies for this question.

• Methotrexate for psoriatic arthritis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Methotrexate vs placebo

The review found no eligible studies for this question.

• Methotrexate for psoriatic arthritis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Routine scale and polish every 6 months vs Routine scale and polish every 12 months

Routine scale and polish every 6 months showed no clear difference in oral health-related quality of life (OHIP-14) compared with routine scale and polish every 12 months (high certainty).

• Routine scale and polish for periodontal health in adults 2018 · Cochrane All outcomes

  36 months
  MD -0.40 [-1.34, 0.54]
  1 study · 786 participants
  High

Intervention not reported

The intervention showed no clear difference in quality of life: Days of work lost per crisis (moderate certainty).

• Drugs for preventing red blood cell dehydration in people with sickle cell disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 145 participants
  Moderate

Acupressure vs sham acupressure

• Acupuncture and acupressure for premenstrual syndrome 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 90 participants
  Low

Idraparinux secondary prophylaxis vs vitamin K antagonist secondary prophylaxis

The review found no eligible studies for this question.

• Anticoagulation for the long‐term treatment of venous thromboembolism in people with cancer 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

L‐ornithine L‐aspartate vs probiotic

The review found no eligible studies for this question.

• L‐ornithine L‐aspartate for prevention and treatment of hepatic encephalopathy in people with cirrhosis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

L‐ornithine L‐aspartate vs rifaximin

The review found no eligible studies for this question.

• L‐ornithine L‐aspartate for prevention and treatment of hepatic encephalopathy in people with cirrhosis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

L‐ornithine L‐aspartate vs lactulose

The review found no eligible studies for this question.

• L‐ornithine L‐aspartate for prevention and treatment of hepatic encephalopathy in people with cirrhosis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Radical multimodality therapy for malignant pleural mesothelioma 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 54 participants
  Low

Intervention not reported

• Radical multimodality therapy for malignant pleural mesothelioma 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 50 participants
  Low

Routine scale and polish at a fixed interval vs No scheduled scale and polish treatment

Planned, regular routine scale and polish (6-monthly; 12-monthly… showed no clear difference in oral health-related quality of life (OHIP-14) compared with no scheduled scale and polish treatment (high certainty).

• Routine scale and polish for periodontal health in adults 2018 · Cochrane All outcomes

  36 months · 6-monthly (12-monthly parallel)
  MD -0.30 [-1.24, 0.64]
  1 study · 795 participants
  High

Music therapy vs psychological treatment

• Music therapy for depression 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 11 participants
  Very low

Retinoic acid post‐consolidation therapy vs no further treatment

The review found no eligible studies for this question.

• Retinoic acid postconsolidation therapy for high‐risk neuroblastoma patients treated with autologous haematopoietic… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Yoga package vs usual care

• Yoga as part of a package of care versus standard care for schizophrenia 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 80 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Sleep positioning systems for children with cerebral palsy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Rilonacept vs indomethacin

The review found no eligible studies for this question.

• Interleukin‐1 inhibitors for acute gout 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Canakinumab vs triamcinolone acetonide

The review found no eligible studies for this question.

• Interleukin‐1 inhibitors for acute gout 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found