Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 25 findings · 17 reviews · Heart

No studies found 1 · 4%GRADE not reported 0 · 0%Very low 1 · 4%Low 8 · 32%Moderate 12 · 48%High 3 · 12%

Intervention not reported

Myocardial infarction (non‐fatal) · people with cardiovascular disease or at high risk of cardiovascular disease

The intervention probably leads to lower myocardial infarction (non‐fatal) (moderate certainty).

1 finding from 1 review

Intervention not reported

Fatal and non‐fatal myocardial infarction · Free‐living adults who were healthy, had established cardiovascular disease or risk factors for cardiovascular disease

The review found no eligible studies for this question.

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

Fatal or nonfatal myocardial infarction · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin probably leads to lower fatal and non‐fatal myocardial infarction compared with aspirin alone (moderate certainty).

1 finding from 1 review

Intervention not reported

Fatal or non‐fatal myocardial infarction ( · people with or at risk of cardiovascular disease

The intervention showed no clear difference in fatal or non‐fatal myocardial infarction ( (moderate certainty).

1 finding from 1 review

Routine invasive strategies vs selective invasive strategies (conservative)

Fatal or nonfatal myocardial infarction · participants with UA/NSTEMI in the stent era

Routine invasive strategies showed no clear difference in death or non‐fatal Myocardial infarction compared with selective invasive strategies (conservative) (low certainty).

1 finding from 1 review

Intervention not reported

Non‐fatal myocardial infarction Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention may leads to lower non‐fatal myocardial infarction Long‐term (low certainty).

1 finding from 1 review

Statins vs Control at 4 months (3 ‐ 6 months)

Fatal & Nonfatal myocardial infarction or reinfarction · patients with acute coronary syndrome

Statins showed no clear difference in fatal and non‐fatal myocardial infarction or reinfarction compared with control at 4 months (3 to 6 months) (moderate certainty).

1 finding from 1 review

Fibrates vs control

Fatal or nonfatal myocardial infarction · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates probably leads to lower myocardial infarction (non‐fatal or fatal) during the treatment and… compared with control (moderate certainty).

2 findings from 1 review

Intervention not reported

ASCVD event, such as fatal or non‐fatal myocardial infarction or stroke. Median · adults older than 18 years, with no restriction regarding presence of ASCVD; participants generally had elevated risk of ASCVD (as…

The intervention showed no clear difference in ASCVD event, such as fatal or non‐fatal myocardial infarction or… (low certainty).

1 finding from 1 review

Fibrates vs control

Stroke, myocardial infarction, or vascular death · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates probably leads to lower composite outcome of non‐fatal stroke, non‐fatal myocardial… compared with control (moderate certainty).

1 finding from 1 review

Intervention not reported

Coronary heart disease (death from cardiovascular causes and non‐fatal myocardial infarction) · Post‐menopausal women

The intervention probably leads to lower coronary heart disease (death from cardiovascular causes and… (moderate certainty).

1 finding from 1 review

Intervention not reported

Coronary heart disease (death from cardiovascular causes and non‐fatal myocardial infarction) · Post‐menopausal women

The intervention showed no clear difference in coronary heart disease (death from cardiovascular causes and… (high certainty).

1 finding from 1 review

Statins vs Control at 4 months (3 ‐ 6 months)

Combined outcome of non‐fatal myocardial infarction, non‐fatal stroke, and total number of deaths · patients with acute coronary syndrome

Statins showed no clear difference in combined outcome of non‐fatal myocardial infarction, non‐fatal… compared with control at 4 months (3 to 6 months) (moderate certainty).

1 finding from 1 review

Intervention not reported

Major cardiovascular events (cardiovascular mortality or non‐fatal myocardial infarction) at maximum · patients without heart failure

The intervention may leads to lower major cardiovascular events (cardiovascular mortality or non‐fatal… (low certainty).

1 finding from 1 review

Fibrates vs control

Composite outcome of non‐fatal stroke, non‐fatal myocardial infarction, and vascular death without clofibrate · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates showed no clear difference in composite outcome of non‐fatal stroke, non‐fatal myocardial… compared with control (low certainty).

1 finding from 1 review