Cochrane · systematic review · CD011114
Vitamin C supplementation for the primary prevention of cardiovascular disease
Al‐Khudairy, L, Flowers, N, Wheelhouse, R, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 5 · 71.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Vitamin C supplementation versus placebo for primary prevention of cardiovascular disease
Population: middle‐aged US male physicians
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Major cardiovascular event Physicians Vitamin C supplementation vs placebo | HR 0.99 [0.89, 1.1] | 1 study · 14641 participants | Low Downgraded: imprecision, indirectness |
Cardiovascular mortality Physicians Vitamin C supplementation vs placebo | HR 1.02 [0.85, 1.22] | 1 study · 14641 participants | Very low Downgraded: imprecision, indirectness |
All‐cause mortality Physicians Vitamin C supplementation vs placebo | HR 1.07 [0.97, 1.18] | 1 study · 14641 participants | Very low Downgraded: imprecision, indirectness |
Total myocardial infarction (fatal and non‐fatal) Physicians Vitamin C supplementation vs placebo | HR 1.04 [0.87, 1.24] | 1 study · 14641 participants | Low Downgraded: imprecision, indirectness |
Total stroke (fatal and non‐fatal) Physicians Vitamin C supplementation vs placebo | HR 0.89 [0.74, 1.07] | 1 study · 14641 participants | Low Downgraded: imprecision, indirectness |
Self‐reported CABG/PTCA Participant self‐reports Vitamin C supplementation vs placebo | HR 0.96 [0.86, 1.07] | 1 study · 14641 participants | Low Downgraded: imprecision, indirectness |
Self‐reported angina Participant self‐reports Vitamin C supplementation vs placebo | HR 0.93 [0.84, 1.03] | 1 study · 14641 participants | Low Downgraded: imprecision, indirectness |