Findings

What do systematic reviews say?

47 questions · 48 findings · 23 reviews · Vascular

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No studies found 6 · 12.5%GRADE not reported 6 · 12.5%Very low 6 · 12.5%Low 17 · 35.4%Moderate 13 · 27.1%High 0 · 0%

Oral factor Xa inhibitors vs conventional anticoagulation

All‐cause mortality · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral factor Xa inhibitors showed no clear difference in all‐cause mortality compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 1.16 [0.79, 1.7]
1 study · 4817 participants
Moderate

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

All‐cause mortality · patients with a pulmonary embolism, confirmed by standard imaging techniques

The review found no eligible studies for this question.

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Duplex ultrasound plus pulse palpation and arterial pressure index (ABI or TBI) vs pulse palpation plus arterial pressure index (ABI or TBI) (long term)

All‐cause mortality · people who underwent a lower limb revascularisation

The review found no eligible studies for this question.

1 finding from 1 review

Duplex ultrasound for surveillance of lower limb revascularisation 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Duplex ultrasound plus pulse palpation and arterial pressure index (ABI or TBI) vs pulse palpation plus arterial pressure index (ABI or TBI) (short term)

All‐cause mortality · people who underwent a lower limb revascularisation

Duplex ultrasound plus pulse palpation and arterial pressure index… showed no clear difference in all‐cause mortality compared with pulse palpation plus arterial pressure index (ABI or TBI) (short term) (low certainty).

1 finding from 1 review

Duplex ultrasound for surveillance of lower limb revascularisation 2023 · Cochrane Headline outcomes only
RR 1.11 [0.7, 1.74]
1 study · 594 participants
Low

IVIg vs acetylsalicylic acid (ASA)

Mortality (all‐cause) · people undergoing initial treatment for KD

1 finding from 1 review

Intravenous immunoglobulin for the treatment of Kawasaki disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Anticoagulant vs placebo or no treatment

All‐cause mortality · non‐hospitalised individuals with COVID‐19 (asymptomatic and mild disease)

Anticoagulant showed no clear difference in all‐cause mortality compared with placebo or no treatment (low certainty).

1 finding from 1 review

Prophylactic anticoagulants for non‐hospitalised people with COVID‐19 2023 · Cochrane Headline outcomes only
RR 0.36 [0.04, 3.61]
5 studies · 1777 participants
Low

Anticoagulant vs antiplatelet agent

All‐cause mortality · non‐hospitalised individuals with COVID‐19 (asymptomatic and mild disease)

1 finding from 1 review

Prophylactic anticoagulants for non‐hospitalised people with COVID‐19 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 279 participants
Moderate

Anticoagulant vs different dose of the same anticoagulant

All‐cause mortality · non‐hospitalised individuals with COVID‐19 (asymptomatic and mild disease)

1 finding from 1 review

Prophylactic anticoagulants for non‐hospitalised people with COVID‐19 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 278 participants
Moderate

Low molecular weight heparin vs no prophylaxis

All‐cause mortality ( · adults undergoing KA

1 finding from 1 review

Interventions for preventing venous thromboembolism in adults undergoing knee arthroscopy 2022 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1978 participants
GRADE not reported

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

All‐cause mortality ( · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes all‐cause mortality ( compared with control (very low certainty).

1 finding from 1 review

Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia 2022 · Cochrane Headline outcomes only
RR 1 [0.15, 6.63]
3 studies · 123 participants
Very low

Corticosteroids vs no corticosteroid use

Mortality (all‐cause) · children diagnosed with Kawasaki disease

1 finding from 1 review

Corticosteroids for the treatment of Kawasaki disease in children 2022 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1075 participants
Moderate

Heparin vs pentasaccharide

All‐cause mortality · people undergoing bariatric surgery

1 finding from 1 review

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 198 participants
Very low

Heparin started before vs after the surgical procedure

All‐cause mortality · people undergoing bariatric surgery

1 finding from 1 review

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Very low

IPC plus pharmacological prophylaxis vs mechanical prophylaxis alone

All‐cause mortality · people undergoing bariatric surgery

1 finding from 1 review

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Low

Higher‐dose heparin vs standard‐dose heparin

All‐cause mortality · people undergoing bariatric surgery

1 finding from 1 review

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 597 participants
Low

Extensive tests vs tests at the physician's discretion

All‐cause mortality1 · people with unprovoked VTE

The review found no eligible studies for this question.

1 finding from 1 review

Effect of testing for cancer on cancer‐ or venous thromboembolism (VTE)‐related mortality and morbidity in people with… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Standard testing plus PET/CT scanning vs standard testing alone

All‐cause mortality1 · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in all‐cause mortality1 compared with standard testing alone (moderate certainty).

1 finding from 1 review

Effect of testing for cancer on cancer‐ or venous thromboembolism (VTE)‐related mortality and morbidity in people with… 2021 · Cochrane Headline outcomes only
OR 1.22 [0.49, 3.04]
2 studies · 1248 participants
Moderate

EDTA vs placebo

All‐cause mortality · atherosclerotic cardiovascular disease

EDTA showed no clear difference in all‐cause mortality compared with placebo (low certainty).

1 finding from 1 review

Chelation therapy for atherosclerotic cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 0.97 [0.73, 1.28]
2 studies · 1792 participants
Low

Gene therapy vs no gene therapy control

All‐cause mortality · peripheral arterial disease

Gene therapy showed no clear difference in all‐cause mortality compared with no gene therapy control (moderate certainty).

1 finding from 1 review

Gene therapy for peripheral arterial disease 2018 · Cochrane Headline outcomes only
OR 0.93 [0.66, 1.31]
12 studies · 1685 participants
Moderate

Extended prophylaxis vs another VTE extended prophylaxis

All‐cause mortalitye · patients with unprovoked venous thromboembolism

The review found no eligible studies for this question.

1 finding from 1 review

Secondary prevention of recurrent venous thromboembolism after initial oral anticoagulation therapy in patients with… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found