What do systematic reviews say?

Summary of findings table ‐ Midwife continuity models vs other models of care

• Midwife continuity of care models versus other models of care for childbearing women 2024 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 4282 participants
  GRADE not reported

Respiratory syncytial virus vaccine vs placebo

Respiratory syncytial virus vaccine showed no clear difference in maternal death compared with placebo (low certainty).

• Respiratory syncytial virus vaccination during pregnancy for improving infant outcomes 2024 · Cochrane Headline outcomes only
  RR 3 [0.12, 73.5]
  3 studies · 7977 participants
  Low

Treatment of eclampsia: lower‐dose regimens vs standard‐dose strategies

It is very uncertain whether treatment of eclampsia: lower‐dose regimens changes maternal death compared with standard‐dose regimens (very low certainty).

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  RR 0.28 [0.03, 2.58]
  1 study · 72 participants
  Very low

Treatment of eclampsia: IV maintenance vs standard IM maintenance regimen

It is very uncertain whether treatment of eclampsia: IV maintenance changes maternal death compared with standard IM maintenance regimen (very low certainty).

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  RR 0.35 [0.04, 3.27]
  1 study · 137 participants
  Very low

Treatment of eclampsia: duration of postpartum maintenance regimen: short vs 24 hours after delivery

The review found no eligible studies for this question.

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prevention of eclampsia: loading dose alone vs loading dose + maintenance regimen

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 462 participants
  Very low

Prevention of eclampsia: IV maintenance vs standard IM maintenance regimen

The review found no eligible studies for this question.

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prevention of eclampsia: short vs standard maintenance regimen (subgroups by type of short regimen)

The review found no eligible studies for this question.

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Treatment of eclampsia: loading dose alone vs loading dose + maintenance regimen

It is very uncertain whether treatment of eclampsia: loading dose alone changes maternal death compared with loading dose plus maintenance dose regimen (very low certainty).

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  RR 2.59 [0.11, 61.75]
  1 study · 80 participants
  Very low

Prevention of eclampsia: higher vs lower IV maintenance regimen

The review found no eligible studies for this question.

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prevention of eclampsia: IV maintenance vs a serial IV bolus regimen

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 200 participants
  Very low

Heparin prophylaxis vs no treatment/placebo

The review found no eligible studies for this question.

• Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Peripartum/postnatal prophylaxis: UFH vs no treatment

The review found no eligible studies for this question.

• Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Peripartum/postnatal prophylaxis (caesarean): LMWH vs UFH

The review found no eligible studies for this question.

• Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Postnatal prophylaxis: LMWH vs no treatment/placebo

• Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 24 participants
  Very low

LMWH prophylaxis vs UFH

The review found no eligible studies for this question.

• Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

TTS/EWS vs usual care

TTS/EWS showed no clear difference in maternal death compared with standard care (moderate certainty).

• Physiological track‐and‐trigger/early warning systems for use in maternity care 2021 · Cochrane Headline outcomes only
  OR 0.8 [0.3, 2.11]
  1 study · 536233 participants
  Moderate

Corticosteroids vs placebo or no treatment

Maternal outcomes: corticosteroids showed no clear difference in maternal death compared with placebo or no treatment (moderate certainty).

• Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth 2020 · Cochrane Headline outcomes only
  RR 1.19 [0.36, 3.89]
  Studies not reported
  Moderate

Intravenous vs intramuscular oxytocin

• Intravenous versus intramuscular prophylactic oxytocin for reducing blood loss in the third stage of labour 2020 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 7028 participants
  Very low

Advance misoprostol distribution/provision to pregnant women for postpartum self‐administration vs usual care

• Advance misoprostol distribution to pregnant women for preventing and treating postpartum haemorrhage 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 299 participants
  Very low