Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

29 questions · 35 findings · 8 reviews · Neonatal

No studies found 25 · 71.4%GRADE not reported 1 · 2.9%Very low 4 · 11.4%Low 0 · 0%Moderate 5 · 14.3%High 0 · 0%

Barbiturate treatment vs placebo or no treatment

Major neurodevelopmental disability at childhood · infants with perinatal asphyxia

It is very uncertain whether barbiturate treatment changes major neurodevelopmental disability compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Barbiturate treatment vs placebo or no treatment

Death or major neurodevelopmental disability · infants with perinatal asphyxia

It is very uncertain whether barbiturate treatment changes death or major neurodevelopmental disability compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Supine midline head position vs any other supine head position

Major neurodevelopmental disability ‒not reported · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

The review found no eligible studies for this question.

1 finding from 1 review

Methylxanthine vs placebo or control

Major neurodevelopmental disability in children aged 18 to 24 months CA · preterm infants at risk of or with apnea; preterm infants undergoing extubation

Methylxanthine probably leads to lower major neurodevelopmental disability at 18 to 24 months compared with placebo or control (moderate certainty).

1 finding from 1 review

Methylxanthine vs placebo or control

Death or major neurodevelopmental disability at 18 to 24 months · preterm infants at risk of or with apnea; preterm infants undergoing extubation

Methylxanthine probably leads to lower death or major neurodevelopmental disability at 18 to 24 months compared with placebo or control (moderate certainty).

1 finding from 1 review

High‐dose vs standard‐dose strategies

Major neurodevelopmental disability in children aged 3 to 5 years CA · preterm infants at risk for apnea

It is very uncertain whether high‐dose changes major neurodevelopmental disability in children aged 3 to 5 years CA compared with standard‐dose strategies (very low certainty).

1 finding from 1 review

High‐dose vs standard‐dose strategies

Major neurodevelopmental disability in children aged 3 to 5 years CA · preterm infants with or at risk for apnea of prematurity

The review found no eligible studies for this question.

3 findings from 1 review