Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

8 questions · 8 findings · 5 reviews · Stroke

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 25%Low 1 · 12.5%Moderate 3 · 37.5%High 2 · 25%

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs placebo/open control

Death from any cause · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Antifibrinolytic drug(s) showed no clear difference in death from any cause compared with placebo/open control (high certainty).

1 finding from 1 review

Summary of findings table ‐ Platelet transfusion vs open control

Death from any cause · adults with acute spontaneous intracerebral haemorrhage associated with antiplatelet drug use

Summary of findings table ‐ Platelet transfusion showed no clear difference in death from any cause compared with open control (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs fresh frozen plasma

Death from any cause · adults with acute spontaneous intracerebral haemorrhage associated with anticoagulant drug use

It is very uncertain whether summary of findings table ‐ Prothrombin complex concentrates changes death from any cause compared with fresh frozen plasma (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Recombinant activated factor VII vs placebo/open control

Death from any cause · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Recombinant activated factor VII showed no clear difference in death from any cause compared with placebo/open control (moderate certainty).

1 finding from 1 review

Endovascular coiling vs neurosurgical clipping

Death from any cause (12 months) · people with subarachnoid haemorrhage from a ruptured intracranial aneurysm

Endovascular coiling showed no clear difference in death from any cause (12 months) compared with neurosurgical clipping (moderate certainty).

1 finding from 1 review

Intervention not reported

Death Number of deaths from any cause at 6‐month · care home residents who have had a stroke

The intervention may leads to lower death Number of deaths from any cause at 6‐month (low certainty).

1 finding from 1 review

Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment

Stroke, myocardial infarction, or vascular death · stroke and/or TIA

Blood pressure‐lowering drugs (BPLDs) showed no clear difference in major vascular event (composite of non‐fatal stroke, non‐fatal… compared with placebo or no treatment (high certainty).

1 finding from 1 review