Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

54 questions · 54 findings · 24 reviews · Haematology

No studies found 4 · 7.4%GRADE not reported 1 · 1.9%Very low 4 · 7.4%Low 20 · 37%Moderate 20 · 37%High 5 · 9.3%

Fewer vs more courses of chemotherapy (with or without radiotherapy

Death · Patients with untreated Hodgkin lymphoma (early stages)

Fewer showed no clear difference in death compared with more courses of chemotherapy (with or without radiotherapy (high certainty).

1 finding from 1 review

Dose‐intensified chemotherapy vs ABVD‐like chemotherapy (with or without radiotherapy

Death · Patients with untreated Hodgkin lymphoma (advanced stages)

Dose‐intensified chemotherapy showed no clear difference in death compared with ABVD‐like chemotherapy (with or without radiotherapy (moderate certainty).

1 finding from 1 review

Chemotherapy alone vs same chemotherapy plus radiotherapy

Death · Patients with untreated Hodgkin lymphoma (early and advanced stages)

Chemotherapy alone showed no clear difference in death compared with same chemotherapy plus radiotherapy (moderate certainty).

1 finding from 1 review

Chemotherapy plus involved‐field radiation vs same chemotherapy plus extended‐field radiation

Death · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus involved‐field radiation showed no clear difference in death compared with same chemotherapy plus extended‐field radiation (high certainty).

1 finding from 1 review

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Death · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in death compared with same chemotherapy plus higher‐dose radiation (high certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Treatment‐related death · All patients with a diagnosis of multiple myeloma

Bortezomib showed no clear difference in treatment‐related death compared with no bortezomib (low certainty).

1 finding from 1 review

Escalated BEACOPP vs chemotherapy including ABVD

Relapse, progression or death (calculated instead of PFS) · Patients with early unfavourable or advanced stage HL

Escalated BEACOPP probably leads to lower progression, relapse or death compared with chemotherapy including ABVD (moderate certainty).

1 finding from 1 review