Intervention not reported
Clinical pregnancy rate · couples trying to conceive
The intervention showed no clear difference in clinical pregnancy rate (low certainty).
1 finding from 1 review
- RR 1.09 [0.51, 2.31]1 study · 148 participantsLow
Findings
What do systematic reviews say?
123 questions · 132 findings · 49 reviews · Gynaecology and Fertility
No studies found 6 · 4.5%GRADE not reported 0 · 0%Very low 55 · 41.7%Low 49 · 37.1%Moderate 21 · 15.9%High 1 · 0.8%
Intervention not reported
Clinical pregnancy rate · couples trying to conceive
It is very uncertain whether the intervention changes clinical pregnancy rate (very low certainty).
1 finding from 1 review
- RR 1.13 [0.31, 4.07]1 study · 17 participantsVery low
Blastocyst‐stage vs cleavage‐stage embryo transfer
Clinical pregnancy rate · Patients with subfertility
Blastocyst‐stage probably leads to higher clinical pregnancy rate compared with cleavage‐stage embryo transfer (moderate certainty).
1 finding from 1 review
- Cleavage‐stage versus blastocyst‐stage embryo transfer in assisted reproductive technology 2022 · Cochrane Headline outcomes onlyOR 1.25 [1.12, 1.39]32 studies · 5821 participantsModerate
Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse
Clinical pregnancy rate · infertile women with polycystic ovary syndrome
Letrozole with or without adjuncts leads to higher clinical pregnancy rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).
1 finding from 1 review
- Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome 2022 · Cochrane Headline outcomes onlyOR 1.69 [1.45, 1.98]23 studies · 3321 participantsHigh
Letrozole vs laparoscopic ovarian drilling
Clinical pregnancy rate · infertile women with polycystic ovary syndrome
Letrozole showed no clear difference in clinical pregnancy rate compared with laparoscopic ovarian drilling (low certainty).
1 finding from 1 review
- Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome 2022 · Cochrane Headline outcomes onlyOR 1.47 [0.95, 2.28]3 studies · 376 participantsLow
Progesterone vs placebo/no treatment
Clinical pregnancy rate · women with gonadotropin stimulation
Progesterone may leads to higher clinical pregnancy rate compared with placebo/no treatment (low certainty).
1 finding from 1 review
- Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes onlyRR 1.38 [1.1, 1.74]7 studies · 1437 participantsLow
Progesterone vs placebo/no treatment
Clinical pregnancy rate · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation
Progesterone may leads to higher clinical pregnancy rate compared with placebo/no treatment (low certainty).
1 finding from 1 review
- Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes onlyRR 1.4 [1.03, 1.9]4 studies · 733 participantsLow
Intramuscular (IM) progesterone vs vaginal progesterone
Clinical pregnancy rate · women trying to conceive by intrauterine insemination
It is very uncertain whether intramuscular (IM) progesterone changes clinical pregnancy rate compared with vaginal progesterone (very low certainty).
1 finding from 1 review
- Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes onlyRR 0.78 [0.55, 1.11]1 study · 225 participantsVery low
Oral progesterone vs vaginal progesterone
Clinical pregnancy rate · women trying to conceive by intrauterine insemination
It is very uncertain whether oral progesterone changes clinical pregnancy rate compared with vaginal progesterone (very low certainty).
1 finding from 1 review
- Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes onlyRR 1.16 [0.69, 1.96]1 study · 150 participantsVery low
Aqueous subcutaneous (Sc) progesterone vs vaginal progesterone
Clinical pregnancy rate · women trying to conceive by intrauterine insemination
It is very uncertain whether aqueous subcutaneous (Sc) progesterone changes clinical pregnancy rate compared with vaginal progesterone gel (very low certainty).
1 finding from 1 review
- Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes onlyRR 1.12 [0.59, 2.11]1 study · 246 participantsVery low
Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment
Clinical pregnancy rate · women trying to conceive by intrauterine insemination
It is very uncertain whether subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist changes clinical pregnancy rate compared with placebo/no treatment (very low certainty).
1 finding from 1 review
- Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes onlyRR 1 [0.68, 1.47]2 studies · 340 participantsVery low
Vaginal progesterone vs GnRH agonist
Clinical pregnancy rate · women trying to conceive by intrauterine insemination
It is very uncertain whether vaginal progesterone changes clinical pregnancy rate compared with gonadotropin‐releasing hormone (GnRH) agonist (very low certainty).
1 finding from 1 review
- Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes onlyRR 1 [0.51, 1.95]1 study · 242 participantsVery low
Human chorionic gonadotropin (hCG) injection vs no treatment
Clinical pregnancy rate · women trying to conceive by intrauterine insemination
It is very uncertain whether human chorionic gonadotropin (hCG) injection changes clinical pregnancy rate compared with no treatment (very low certainty).
1 finding from 1 review
- Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes onlyRR 0.93 [0.4, 2.13]1 study · 130 participantsVery low
Pentoxifylline vs placebo
Clinical pregnancy rate · women with endometriosis
It is very uncertain whether pentoxifylline changes clinical pregnancy rate compared with placebo (very low certainty).
1 finding from 1 review
- Pentoxifylline for the treatment of endometriosis‐associated pain and infertility 2021 · Cochrane Headline outcomes onlyRR 1.38 [0.91, 2.1]3 studies · 285 participantsVery low
Dopamine agonist vs other active intervention
Clinical pregnancy rate · women undergoing assisted reproduction
Dopamine agonist showed no clear difference in clinical pregnancy rate compared with other active intervention (moderate certainty).
1 finding from 1 review
- Dopamine agonists for preventing ovarian hyperstimulation syndrome 2021 · Cochrane Headline outcomes onlyOR 1.04 [0.81, 1.33]7 studies · 1060 participantsModerate
Dopamine agonist vs placebo or no intervention
Clinical pregnancy rate · women undergoing assisted reproduction
Dopamine agonist showed no clear difference in clinical pregnancy rate compared with placebo/no intervention (low certainty).
1 finding from 1 review
- Dopamine agonists for preventing ovarian hyperstimulation syndrome 2021 · Cochrane Headline outcomes onlyOR 0.92 [0.63, 1.37]5 studies · 530 participantsLow
Dopamine agonist plus co‐intervention vs co‐intervention
Clinical pregnancy rate · women undergoing assisted reproduction
Dopamine agonist plus co‐intervention showed no clear difference in clinical pregnancy rate compared with co‐intervention (low certainty).
1 finding from 1 review
- Dopamine agonists for preventing ovarian hyperstimulation syndrome 2021 · Cochrane Headline outcomes onlyOR 1.11 [0.83, 1.49]4 studies · 748 participantsLow
Analysis 1 ‐ Oxidised regenerated cellulose vs no treatment at laparotomy
Clinical pregnancy rate · women having gynaecological surgery
The review found no eligible studies for this question.
1 finding from 1 review
- Barrier agents for adhesion prevention after gynaecological surgery 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Gore‐Tex vs oxidised regenerated cellulose
Clinical pregnancy rate · women having gynaecological surgery
The review found no eligible studies for this question.
1 finding from 1 review
- Barrier agents for adhesion prevention after gynaecological surgery 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Analysis 7 ‐ Collagen membrane with polyethylene glycol and glycerol vs Ringer's lactate
Clinical pregnancy rate · patients with adhesion prevention after gynaecological surgery
It is very uncertain whether analysis 7 ‐ Collagen membrane with polyethylene glycol and glycerol changes clinical pregnancy rate compared with ringer's lactate (very low certainty).
1 finding from 1 review
- Barrier agents for adhesion prevention after gynaecological surgery 2020 · Cochrane Headline outcomes onlyOR 5.69 [1.38, 23.48]1 study · 39 participantsVery low