Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

56 questions · 64 findings · 20 reviews · Neonatal

No studies found 14 · 21.9%GRADE not reported 9 · 14.1%Very low 13 · 20.3%Low 16 · 25%Moderate 12 · 18.8%High 0 · 0%

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Chronic lung disease · ventilated preterm infants with failure of initial non‐invasive respiratory support

nHFV showed no clear difference in chronic lung disease compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).

1 finding from 1 review

Lactoferrin supplementation with enteral feeds in combination with probiotics vs placebo

Chronic lung disease · prevention of sepsis and necrotizing enterocolitis in preterm infants

It is very uncertain whether lactoferrin supplementation with enteral feeds in combination with… changes chronic lung disease compared with placebo (very low certainty).

1 finding from 1 review