Findings

What do systematic reviews say?

8 questions · 8 findings · 5 reviews · Neonatal

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No studies found 3 · 37.5%GRADE not reported 0 · 0%Very low 4 · 50%Low 1 · 12.5%Moderate 0 · 0%High 0 · 0%

Fentanyl vs tramadol

All‐cause mortality during hospital stay · postoperative pain in preterm and term infants

It is very uncertain whether fentanyl changes all‐cause mortality during initial hospitalization compared with tramadol (very low certainty).

1 finding from 1 review

Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
RR 0.99 [0.59, 1.64]
1 study · 171 participants
Very low

Morphine vs paracetamol

All‐cause mortality during hospital stay · postoperative pain in preterm and term infants

The review found no eligible studies for this question.

1 finding from 1 review

Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Tramadol vs no treatment or placebo

All‐cause mortality during hospital stay · postoperative pain in preterm and term infants

It is very uncertain whether tramadol changes all‐cause mortality during initial hospitalization compared with no treatment or placebo (very low certainty).

1 finding from 1 review

Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
RR 0.32 [0.01, 7.7]
1 study · 71 participants
Very low

Cuffed vs uncuffed endotracheal tubes

All‐cause mortality during hospital stay · neonates

It is very uncertain whether cuffed (inflated or not) changes all‐cause mortality during initial hospitalization compared with uncuffed endotracheal tubes (very low certainty).

1 finding from 1 review

Cuffed versus uncuffed endotracheal tubes for neonates 2022 · Cochrane Headline outcomes only
RR 2.46 [0.1, 58.39]
1 study · 69 participants
Very low

Clonidine vs placebo

All‐cause mortality during hospital stay · neonates with mechanical ventilation

Clonidine showed no clear difference in all‐cause mortality during initial hospitalization compared with placebo (low certainty).

1 finding from 1 review

Clonidine for sedation and analgesia for neonates receiving mechanical ventilation 2017 · Cochrane Headline outcomes only
RR 0.69 [0.12, 3.98]
1 study · 112 participants
Low

Continuous glucose monitoring system vs intermittent modalities

All‐cause mortality during initial hospitalization ‐ not reported · infants at risk of hypoglycaemia or hyperglycaemia

It is very uncertain whether summary of findings table ‐ Continuous glucose monitoring (CGM) changes death during initial hospitalization (all‐cause mortality) compared with intermittent modalities (very low certainty).

1 finding from 1 review

Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants 2021 · Cochrane Headline outcomes only
RR 0.59 [0.16, 2.13]
2 studies · 230 participants
Very low

Continuous infusion vs bolus administration

All‐cause mortality during initial hospitalization ‐ not reported · postoperative pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Systemic opioid regimens for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

'As needed' administration (e.g. based on pain scales) vs 'as scheduled' administration (e.g. a predefined time interval)

All‐cause mortality during initial hospitalization ‐ not reported · postoperative pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Systemic opioid regimens for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found