What do systematic reviews say?

Adjuvant chemotherapy vs no chemotherapy

It is very uncertain whether adjuvant chemotherapy changes all‐cause mortality at 5 years compared with no chemotherapy (very low certainty).

• Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma 2021 · Cochrane Headline outcomes only
  RR 0.92 [0.84, 1.01]
  4 studies · 867 participants
  Very low

Surgical portosystemic shunts vs transjugular intrahepatic portosystemic shunt (TIPS)

It is very uncertain whether surgical portosystemic shunts changes all‐cause mortality at 5 years compared with transjugular intrahepatic portosystemic shunt (TIPS) (very low certainty).

• Surgical portosystemic shunts versus transjugular intrahepatic portosystemic shunt for variceal haemorrhage in people… 2018 · Cochrane Headline outcomes only
  RR 0.61 [0.42, 0.9]
  4 studies · 496 participants
  Very low

TACE followed by 3‐DCRT vs chemoembolisation

TACE followed by 3‐DCRT may leads to lower all‐cause mortality: at 3 years compared with TACE (low certainty).

• Transcatheter arterial chemoembolisation followed by three‐dimensional conformal radiotherapy versus transcatheter… 2019 · Cochrane Headline outcomes only
  RR 0.8 [0.73, 0.88]
  7 studies · 552 participants
  Low

Intervention not reported

• Glucocorticosteroids for infants with biliary atresia following Kasai portoenterostomy 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low