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Evidence found and GRADE certainty

83 questions · 83 findings · 29 reviews

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No studies found 25 · 30.1%GRADE not reported 2 · 2.4%Very low 21 · 25.3%Low 20 · 24.1%Moderate 13 · 15.7%High 2 · 2.4%

Intervention not reported

Adverse events ‐ minor Infections Clinical events experienced by children during the 1 year period commencing at entry to the trial · 117 children with homozygous sickle cell (SS) disease

The intervention showed no clear difference in adverse events ‐ minor Infections Clinical events experienced by… (low certainty).

1 finding from 1 review

Intervention not reported

Minor adverse events** ‒short‐term (> 2 weeks but ≤ 3 months) Minor adverse events provided as the proportion of patients reporting any untoward medical occurrence after an epidural injection without hospitalisations. · lumbosacral radicular pain

It is very uncertain whether the intervention changes minor adverse events** ‒short‐term (> 2 weeks but ≤ 3 months) Minor… (very low certainty).

1 finding from 1 review

Application of heat vs application of cold

Adverse events due to treatment Minor adverse events, reported in studies as: exacerbation in pain after treatment; burn as a result of hot‐water immersion, or transient erythema, or adverse effects due to application of ice · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes adverse events due to treatment Minor adverse events, reported in… compared with application of cold (very low certainty).

1 finding from 1 review