Cochrane · systematic review · CD011130
Folate supplementation in people with sickle cell disease
Dixit, R, Nettem, S, Madan, SS, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 87.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsSummary of findings
Population: 117 children with homozygous sickle cell (SS) disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes1 | no estimate extracted | NR | No studies |
Folate concentration Serum folate levels, measured between 6 and 12 months after entry to the study | no estimate extracted | 1 study · 80 participants | Low Downgraded: risk of bias |
Haemoglobin concentration Haematological analyses were performed in the 100/115 (87%) children in whom baseline (within 2 months of entry to study) and 1 year (between 10 and 14 months after entry) | no estimate extracted | 1 study · 100 participants | Low Downgraded: risk of bias |
Adverse events ‐ acute splenic sequestration Clinical events experienced by children during the 1 year period commencing at entry to the trial | RR 1.07 [0.44, 2.57] | 1 study · 115 participants | Low Downgraded: risk of bias |
Adverse events ‐ painful episodes Clinical events experienced by children during the 1 year period commencing at entry to the trial | RR 1.16 [0.7, 1.92] | 1 study · 115 participants | Low Downgraded: risk of bias |
Adverse events ‐ minor Infections Clinical events experienced by children during the 1 year period commencing at entry to the trial | RR 0.99 [0.85, 1.15] | 1 study · 115 participants | Low Downgraded: risk of bias |
Adverse events ‐ major infections Clinical events experienced by children during the 1 year period commencing at entry to the trial | RR 0.89 [0.47, 1.66] | 1 study · 115 participants | Low Downgraded: risk of bias |
Adverse events ‐ dactylitis Clinical events experienced by children during the 1 year period commencing at entry to the trial | RR 0.67 [0.37, 1.27] | 1 study · 115 participants | Low Downgraded: risk of bias |