Findings

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Open surgery vs steroid injection plus hyaluronic acid injection guided by ultrasound

Adverse events (partial loss of movement, algodystrophic syndrome) · patients with trigger finger

It is very uncertain whether open surgery changes adverse events (partial loss of movement, algodystrophic syndrome) compared with steroid injection plus hyaluronic acid injection guided by ultrasound (very low certainty).

1 finding from 1 review

On‐demand deprescribing vs continued use

Adverse drug withdrawal events ‐ esophagitis (endoscopic findings) · people with moderate GERD and mild esophagitis, mean age 48 to 57 years

On‐demand deprescribing may leads to higher adverse drug withdrawal events ‐ esophagitis (endoscopic findings) compared with continued use (low certainty).

1 finding from 1 review

Non‐platinum single‐agent vs non‐platinum combination treatment

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · non‐small cell lung cancer in the elderly population

It is very uncertain whether non‐platinum single‐agent changes grade 3 and 4 hematological adverse events (AE) ‐ thrombocytopenia compared with non‐platinum combination treatment (very low certainty).

1 finding from 1 review

IVIg vs PE

Number of patients with adverse events attributed to treatment · patients with Guillain‐Barré syndrome

IVIg showed no clear difference in number of participants with adverse events attributed to treatment compared with PE (moderate certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · patients with schizophrenia

Perazine showed no clear difference in overall tolerability Leaving the study early due to adverse events compared with other antipsychotics (low certainty).

1 finding from 1 review

Integrated securement dressings vs standard polyurethane

Adverse events assessed during catheter dwell or on product removal · people with arterial catheter dressing and securement

Integrated securement dressings showed no clear difference in adverse events assessed during catheter dwell or on product removal compared with standard polyurethane (low certainty).

1 finding from 1 review

Pexastimogene devacirepvec (Pexa‐Vec) plus best supportive care vs best supportive care

Proportion of people with ≥ 1 serious adverse events (at 20 months) · participants with advanced hepatocellular carcinoma

It is very uncertain whether pexastimogene devacirepvec (Pexa‐Vec) plus best supportive care changes proportion of people with ≥ 1 serious adverse events (at 20 months) compared with best supportive care alone (very low certainty).

1 finding from 1 review

Zinc vs placebo

Adverse events number of participants hospitalised during the trial · children with cystic fibrosis

Summary of findings: Zinc supplementation showed no clear difference in adverse events number of participants hospitalised during the trial compared with placebo (moderate certainty).

1 finding from 1 review

Active cancer therapy combined with TCM vs active cancer therapy

Adverse events ‐ gastrointestinal reactions Diagnosed by clinicians · patients with oesophageal cancer

It is very uncertain whether active cancer therapy combined with TCM changes adverse events ‐ gastrointestinal reactions Diagnosed by clinicians compared with active cancer therapy (very low certainty).

1 finding from 1 review

Amantidine vs antidepressants

Risk for at least one adverse event per patient · patients with the treatment of cocaine dependence

Amantidine showed no clear difference in adverse events as N of participants with at least one adverse event compared with antidepressants (low certainty).

1 finding from 1 review