Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Amifostine vs no treatment/placebo

Adverse effects (other reported events) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Zonisamide vs placebo

Adverse events Number of adverse events · patients with essential tremor

It is very uncertain whether zonisamide changes adverse events Number of adverse events compared with placebo (very low certainty).

1 finding from 1 review

Pilocarpine vs no treatment/placebo

Adverse effects (other reported events) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Xylitol vs control

Gastrointestinal adverse events · preventing acute otitis media in children up to 12 years of age

Xylitol showed no clear difference in gastrointestinal‐related adverse events compared with control (moderate certainty).

3 findings from 1 review

Intervention not reported

Adverse events Number of adverse events · patients with essential tremor

It is very uncertain whether the intervention changes adverse events Number of adverse events (very low certainty).

1 finding from 1 review

Primary comparison for continuous passive motion (CPM) vs no CPM

Adverse events (a count of reported harms or adverse events/experiences over life of study/ · hospitalised patients who have undergone knee replacement surgery

Primary comparison for continuous passive motion (CPM) showed no clear difference in adverse events Counts of adverse events compared with no CPM (low certainty).

1 finding from 1 review

Summary of findings table ‐ Deep neuromuscular blockade (NMB) vs moderate NMB

Short‐term serious adverse events (SAEs) · adults undergoing intra‐ and transperitoneal laparoscopic procedures

It is very uncertain whether summary of findings table ‐ Deep neuromuscular blockade (NMB) changes short‐term serious adverse events (SAEs) compared with moderate NMB (very low certainty).

1 finding from 1 review