Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Tocilizumab every 4 weeks vs placebo

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab every 4 weeks showed no clear difference in adverse events at ≥ 12 months compared with placebo (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 52‐week taper

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly showed no clear difference in adverse events at ≥ 12 months compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 26‐week taper

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly showed no clear difference in adverse events at ≥ 12 months compared with placebo + 26‐week taper (moderate certainty).

1 finding from 1 review

Statins with cholesterol supplementation vs cholesterol supplementation only

Statin‐related adverse events · children and adults with Smith‐Lemli‐Opitz syndrome

It is very uncertain whether statins with cholesterol supplementation changes statin‐related adverse events compared with cholesterol supplementation only (very low certainty).

1 finding from 1 review