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Interferon‐α alone probably leads to lower adverse events (grade ≥ 3) compared with interferon‐α plus bevacizumab (moderate certainty).
Interferon‐α plus bevacizumab showed no clear difference in adverse events (grade ≥ 3) compared with standard targeted therapies (low certainty).
Vaccine treatment showed no clear difference in adverse events (grade ≥ 3) compared with standard therapies (low certainty).
Targeted immunotherapy alone probably leads to lower adverse events (grade ≥ 3) compared with standard targeted therapies (moderate certainty).
Interferon‐α alone may leads to higher adverse events (grade ≥ 3) compared with standard targeted therapies (sunitinib or temsirolimus) (low certainty).
Surgery probably leads to lower adverse events at 4 months compared with oral medication (moderate certainty).
It is very uncertain whether the intervention changes adverse events: drowsiness (very low certainty).
Methotrexate probably leads to higher significant adverse events compared with placebo (moderate certainty).
The review found no eligible studies for this question.
Testosterone therapy showed no clear difference in adverse events (all cause) compared with placebo (low certainty).
It is very uncertain whether doxepin cream changes adverse events (somnolence) compared with oral antihistamine (very low certainty).
Gabapentin may leads to lower adverse events (somnolence) compared with cetirizine (antihistamine) (low certainty).
Pregabalin may leads to lower adverse events (drowsiness) compared with cetirizine with pheniramine maleate (antihistamine) (low certainty).
The intervention may leads to higher adverse events – arrhythmia (low certainty).