Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,949 questions · 1,994 findings · 636 reviews

No studies found 504 · 25.3%GRADE not reported 340 · 17.1%Very low 477 · 23.9%Low 390 · 19.6%Moderate 241 · 12.1%High 42 · 2.1%

Nifedipine vs placebo

Bothersome adverse effects · primary dysmenorrhoea

It is very uncertain whether nifedipine changes bothersome adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Rufinamide vs placebo

Frequency of adverse effects ‐ dizziness ( · people with drug‐resistant focal epilepsy

Rufinamide probably leads to higher adverse effects: dizziness compared with placebo (moderate certainty).

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Adverse effects: hot flush · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist plus chemotherapy changes adverse effects: hot flush compared with chemotherapy alone (very low certainty).

1 finding from 1 review

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Adverse effects of therapy · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination
1 finding from 1 review

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Adverse effects of therapy · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants (trazodone 200 mg/day) vs placebo

Frequency of adverse effects ‐ dizziness ( · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether antidepressants (trazodone 200 mg/day) changes adverse effects: dizziness compared with placebo (very low certainty).

1 finding from 1 review

Benzodiazepines (topical clonazepam) vs placebo

Adverse effects: dry mouth · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether benzodiazepines (topical clonazepam) changes adverse effects: dry mouth compared with placebo (very low certainty).

1 finding from 1 review

Antidepressants (trazodone 200 mg/day) vs placebo

Adverse effects: dry mouth · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether antidepressants (trazodone 200 mg/day) changes adverse effects: dry mouth compared with placebo (very low certainty).

1 finding from 1 review