Cochrane · systematic review · CD011503
Valacyclovir versus acyclovir for the treatment of herpes zoster ophthalmicus in immunocompetent patients
Schuster, AK, Harder, BC, Schlichtenbrede, FC, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: Adult immunocompetent patients with herpes zoster ophthalmicus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Occurrence of ocular involvement | RR 1.93 [0.18, 20.65] | 1 study · 110 participants | Very low Downgraded: risk of bias |
Ocular involvement ‐ Dendritic ulcer | RR 2.89 [0.31, 26.96] | 1 study · 110 participants | Very low Downgraded: risk of bias |
Ocular involvement ‐ Uveitis | RR 0.96 [0.36, 2.57] | 1 study · 110 participants | Very low Downgraded: risk of bias |
Pain at week 24 (self‐reported; yes) | RR 0.96 [0.2, 4.57] | 1 study · 110 participants | Very low Downgraded: risk of bias |
Adverse effects ‐ Vomiting | RR 1.45 [0.25, 8.32] | 1 study · 110 participants | Very low Downgraded: risk of bias |
Adverse effects ‐ Eyelid or facial oedema | RR 0.32 [0.03, 3] | 1 study · 110 participants | Very low Downgraded: risk of bias |
Adverse effects ‐ Disseminated zoster | RR 0.32 [0.01, 7.73] | 1 study · 110 participants | Very low Downgraded: risk of bias |