Adverse effects (urticaria) Defined as participants reporting urticaria (hives) Dose: 2 g per day · school‐aged children (6 to 15 years) and marine corps recruits (mean age 18.5 years)
It is very uncertain whether vitamin C changes adverse effects (urticaria) Defined as participants reporting… compared with placebo (very low certainty).
1 finding from 1 review
Adverse effects (side effects; treatment withdrawals) · participants with acne
Benzoyl peroxide may leads to higher withdrawal due to adverse effects (long‐term data) Treatment… compared with placebo or no treatment (low certainty).
1 finding from 1 review
Withdrawals due to adverse outcomes · participants with acne
It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (long‐term data) Treatment… compared with adapalene (very low certainty).
1 finding from 1 review
Adverse effects (side effects; treatment withdrawals) · participants with acne
It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (long‐term data) Treatment… compared with clindamycin (very low certainty).
1 finding from 1 review
Adverse effects: extrapyramidal adverse effects Parkinsonism short term (< 3 months) not reported · patients with schizophrenia or related psychoses
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects of antibiotics: proportion of participants with one or more serious adverse event · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
Cycled inhaled tobramycin (TNS) probably leads to lower adverse effects of antibiotics: proportion of participants with one… compared with culture‐based TNS (moderate certainty).
1 finding from 1 review
Surgically‐related severe adverse effects (grade 3+) ‐ stoma formation (within 30 days of surgery) · women with advanced ovarian epithelial cancer
Neoadjuvant chemotherapy prior to interval surgery (NACT) probably leads to lower surgically‐related severe adverse effects (grade 3+) ‐ stoma… compared with surgery followed by chemotherapy (PDS) (moderate certainty).
1 finding from 1 review
Surgically‐related severe adverse effects (grade 3+) ‐ bowel resection (within 30 days of surgery) · women with advanced ovarian epithelial cancer
Neoadjuvant chemotherapy prior to interval surgery (NACT) probably leads to lower surgically‐related severe adverse effects (grade 3+) ‐ bowel… compared with surgery followed by chemotherapy (PDS) (moderate certainty).
1 finding from 1 review
Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis
Guselkumab showed no clear difference in proportion of participants with adverse effects serious or severe… compared with placebo (low certainty).
1 finding from 1 review
Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis
Secukinumab probably leads to higher proportion of participants with adverse effects serious or severe… compared with placebo (moderate certainty).
1 finding from 1 review
Adverse effects: Specific ‐ hypertonia/rigidity (only reported if occurred in ≥9%) during 24 hours · patients with psychosis‐induced aggression or agitation
It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ hypertonia/rigidity (only reported if… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).
1 finding from 1 review
Adverse effects: Specific ‐ hypertonia/rigidity (only reported if occurred in ≥9%) during 24 hours · patients with psychosis‐induced aggression or agitation
It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ hypertonia/rigidity (only reported if… compared with BENZODIAZEPINE: b. LORAZEPAM (very low certainty).
1 finding from 1 review
Adverse effects: incidence of serious adverse effects. Movement disorders ‐ dyskinesia ‐short‐term · patients with schizophrenia
It is very uncertain whether chlorpromazine changes adverse effects: incidence of serious adverse effects. Movement… compared with clotiapine (very low certainty).
1 finding from 1 review
Adverse effects: extrapyramidal adverse effects Parkinsonismmedium term (3‐12 months) not reported · patients with schizophrenia or related psychoses
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Harms: non-serious adverse effects (headache, discomfort, loosening of temporary anchorage devices) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances
Light vibrational forces (LVF) showed no clear difference in harms: non-serious adverse effects (headache, discomfort, loosening… compared with conventional orthodontic appliance treatment (placebo or no adjunct); GRADE not reported.
1 finding from 1 review
Adverse effects: Parkinsonism ‐ average endpoint score (SAS, high = worse) · people with psychosis
1 finding from 1 review
Adverse effects sufficient to stop treatment · Children aged 6 to 18 years with ASD
Memantine showed no clear difference in adverse effects Assessed by the study authors as those that were… compared with placebo (low certainty).
1 finding from 1 review
Failure of treatment and adverse effects: long‐term Participants with surgery and symptom recurrence · Adults with isolated cartilage defects (defect areas 1.0 cm2 to 6.0 cm2) of the knee
It is very uncertain whether mosaicplasty changes failure of treatment and adverse effects: long‐term Participants… compared with microfracture (very low certainty).
1 finding from 1 review
Adverse effects: 5a. Movement disorders ‐ specific symptoms ‐ EPS: unspecified ‐ versus standard‐lower dose (greater than or equal to 4‐<6 mg/day) · patients with schizophrenia
STANDARD‐HIGHER DOSE (greater than or equal to 6‐<10 mg/day) showed no clear difference in adverse effects: EPS: unspecified ‐ Versus standard‐lower dose… compared with ANY DOSE ‐ short term (moderate certainty).
1 finding from 1 review
Adverse effects: 6. Movement disorders ‐ specific symptoms ‐ EPS: unspecified ‐ versus low dose (greater than or equal to 2‐<4 mg/day) · patients with schizophrenia
HIGH DOSE (greater than or equal to 10 mg/day) probably leads to higher adverse effects: EPS: unspecified ‐ when compared with low dose… compared with ANY DOSE ‐ short term (moderate certainty).
1 finding from 1 review