Zonisamide vs placebo
Zonisamide probably leads to higher adverse effects: nausea (whole treatment period; any dose) compared with placebo (moderate certainty).
- RR 1.15 studies · 805 participantsModerate
Zonisamide probably leads to higher adverse effects: nausea (whole treatment period; any dose) compared with placebo (moderate certainty).
It is very uncertain whether summary of findings: lorazepam changes number of adverse events including extrapyramidal effectsc compared with chlorpromazine (very low certainty).
Oral miltefosine (50 mg for 28 days) probably leads to higher adverse effects (number of participants who had the event) compared with placebo (same regimen) (moderate certainty).
Oral miltefosine (1.2 to 3.3 mg/kg/d 28 days) probably leads to higher adverse effects (number of participants who had the event) compared with meglumine antimoniate (20 mg/kg 20 days) (moderate certainty).
The review found no eligible studies for this question.
It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ acute dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (very low certainty).
Acupuncture probably leads to lower number of participants dropping out due to adverse effects compared with prophylactic drugs (moderate certainty).
Acupuncture showed no clear difference in number of participants dropping out due to adverse effects compared with sham interventions (low certainty).
Adalimumab every other week showed no clear difference in proportion of participants with infectious adverse effects compared with placebo (high certainty).
Adalimumab weekly showed no clear difference in proportion of participants with infectious adverse effects compared with placebo (moderate certainty).
Beta‐blockers showed no clear difference in adverse effects: 3. Specific ‐ cardiovascular ‐ short term compared with placebo (low certainty).
It is very uncertain whether part-time clear plastic (removable) retainer changes adverse effects on oral health: Gingival Index (lower arch) compared with any type of fixed (bonded) retainer (very low certainty).
CAD/CAM nitinol fixed (bonded) retainer showed no clear difference in adverse effects on oral health: Gingival Index (lower arch) compared with conventional/analogue multistrand fixed (bonded) retainer (low certainty).
First‐line thiazides may leads to lower withdrawals due to adverse effects Duration: 1 to 3.2 years compared with first‐line alpha‐blockers (low certainty).
The review found no eligible studies for this question.
NSAID showed no clear difference in maternal drug adverse effects(6 hours after administration) compared with placebo (low certainty).
Zonisamide probably leads to higher adverse effects: fatigue (whole treatment period; any dose) compared with placebo (moderate certainty).