What do systematic reviews say?

Chronic MND: Cervical/UE Stretch/ROM Exercise + Cervical/UE Strengthening + Dynamic Cervical Stabilization vs sham

The review found no eligible studies for this question.

• Exercises for mechanical neck disorders 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Chronic MND: Cervical Stretch/ROM Exercises + Dynamic Cervical Stabilization vs sham

The review found no eligible studies for this question.

• Exercises for mechanical neck disorders 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Chronic MND: Cervical/Scapulothoracic/UE Stretch + UE Endurance Training vs no treatment or waiting list

The review found no eligible studies for this question.

• Exercises for mechanical neck disorders 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acute to Chronic MND: Scapulothoracic/UE Endurance Training vs control

Acute to Chronic MND: Scapulothoracic/UE Endurance Training led to lower adverse effects compared with CONTROL; GRADE not reported.

• Exercises for mechanical neck disorders 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 participants
  GRADE not reported

Subacute to Chronic WAD: Trunk/Extremity Stretch/ROM + Trunk/Extremity Strengthening + Trunk/Extremity Endurance Training + Pattern/Synchronization: Coordination + Cardiovascular/Aerobic + Cognitive (CBT) + ANOTHER TREATMENT vs THAT SAME OTHER TREATMENT

• Exercises for mechanical neck disorders 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 3 participants
  GRADE not reported

Acute to Chronic MND: Scapulothoracic + UE Strengthening vs control

The review found no eligible studies for this question.

• Exercises for mechanical neck disorders 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Chronic MND: Cervical/UE Stretch/ROM Exercises + Cervical/Scapulothoracic+/‐UE Strengthening + Dynamic/Static Cervical Stabilization + ANOTHER INTERVENTION vs THAT SAME INTERVENTION

• Exercises for mechanical neck disorders 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 8 participants
  GRADE not reported

Intervention not reported

The review found no eligible studies for this question.

• Tailored interventions to address determinants of practice 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Sleep positioning systems for children with cerebral palsy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Tacrolimus 0.03% vs Topical tacrolimus

Tacrolimus 0.03% showed no clear difference in adverse effects compared with tacrolimus 0.1% (moderate certainty).

• Topical tacrolimus for atopic dermatitis 2015 · Cochrane Headline outcomes only
  RR 0.95 [0.86, 1.06]
  4 studies · 986 participants
  Moderate

Tacrolimus 0.1% vs ciclosporin

It is very uncertain whether tacrolimus 0.1% changes adverse effects compared with ciclosporin (very low certainty).

• Topical tacrolimus for atopic dermatitis 2015 · Cochrane Headline outcomes only
  RR 1 [0.31, 3.28]
  1 study · 30 participants
  Very low

Omega‐3 vs placebo

Omega 3 fatty acids leads to higher adverse effects compared with placebo (high certainty).

• Omega 3 fatty acids for preventing or slowing the progression of age‐related macular degeneration 2015 · Cochrane Headline outcomes only
  RR 1.01
  2 studies · 2343 participants
  High

Alginate dressing vs plain non‐adherent dressing

• Alginate dressings for venous leg ulcers 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Alginate dressing vs alternative alginate dressing (Tegagen™ High Gelling)

• Alginate dressings for venous leg ulcers 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Intervention not reported

• Corneal collagen cross‐linking for treating keratoconus 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 3 participants
  GRADE not reported

Cessation of water fluoridation (fluoride removed from the water supply) vs Continued fluoridated water

The review found no eligible studies for this question.

• Water fluoridation for the prevention of dental caries 2015 · Cochrane All outcomes
  No evidence to determine whether cessation of a water fluoridation programme is associated with any harms.
  0 studies
  No studies found

Xylitol wipes (4.2 g/day) vs Control wipes (no xylitol)

• Xylitol‐containing products for preventing dental caries in children and adults 2015 · Cochrane All outcomes

  12 months
  The authors reported that there were no adverse effects for either group. Zhan 2012.
  1 study · 44 participants
  GRADE not reported

Diazepam gel vs Placebo gel

Diazepam gel showed no clear difference in adverse effects compared with placebo gel (moderate certainty).

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  RR 1.5 [0.94, 2.37]
  2 studies · 165 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 264 participants
  Very low

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Lorazepam IV showed no clear difference in adverse effects compared with diazepam plus phenytoin IV (moderate certainty).

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  RR 0.85 [0.63, 1.15]
  2 studies · 370 participants
  Moderate