Aminophylline vs placebo: Return of spontaneous circulation
Aminophylline showed no clear difference in return of spontaneous circulation compared with placebo (high certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Aminophylline vs placebo Return of spontaneous circulation · participants with bradyasystolic cardiac arrest in adults Aminophylline showed no clear difference in return of spontaneous circulation compared with placebo (high certainty). Aminophylline for bradyasystolic cardiac arrest in adults (2015) · Cochrane Headline outcomes only | OR 1.15 [0.89, 1.49] | 5 studies · 1254 participants | High |
Aminophylline vs placebo Early administration of aminophylline: return of spontaneous circulation · participants with bradyasystolic cardiac arrest in adults Aminophylline showed no clear difference in early administration of aminophylline: return of spontaneous… compared with placebo (low certainty). Aminophylline for bradyasystolic cardiac arrest in adults (2015) · Cochrane Headline outcomes only | OR 1.61 [0.38, 6.77] | 2 studies · 37 participants | Low |
Aminophylline vs placebo Return of spontaneous circulation · participants with bradyasystolic cardiac arrest in adults Aminophylline showed no clear difference in return of spontaneous circulation compared with placebo (high certainty). Aminophylline for bradyasystolic cardiac arrest in adults (2013) · Cochrane Headline outcomes onlyearlier version CD006781.PUB2, superseded | OR 1.15 [0.89, 1.49] | 5 studies · 1254 participants | High |
Aminophylline vs placebo Early administration of aminophylline: return of spontaneous circulation · participants with bradyasystolic cardiac arrest in adults Aminophylline showed no clear difference in early administration of aminophylline: return of spontaneous… compared with placebo (low certainty). Aminophylline for bradyasystolic cardiac arrest in adults (2013) · Cochrane Headline outcomes onlyearlier version CD006781.PUB2, superseded | OR 1.61 [0.38, 6.77] | 2 studies · 37 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Aminophylline for bradyasystolic cardiac arrest in adults 2015 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.