Cochrane · systematic review · CD006781
Aminophylline for bradyasystolic cardiac arrest in adults
Hurley, KF, Magee, K, Green, R · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 2 · 33.3%High 1 · 16.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAminophylline compared to placebo for bradyasystolic cardiac arrest in adults
Population: participants with bradyasystolic cardiac arrest in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Survival to hospital discharge Aminophylline vs placebo | OR 0.58 [0.12, 2.74] | 5 studies · 1254 participants | Moderate Downgraded: risk of bias, imprecision |
Return of spontaneous circulation Aminophylline vs placebo | OR 1.15 [0.89, 1.49] | 5 studies · 1254 participants | High |
Survival to admission Aminophylline vs placebo | OR 0.92 [0.61, 1.39] | 4 studies · 1232 participants | Moderate |
Early administration of aminophylline: survival to hospital discharge Aminophylline vs placebo | no estimate extracted | 2 studies · 37 participants | Low |
Early administration of aminophylline: survival to hospital admission Aminophylline vs placebo | OR 0.22 [0.02, 2.36] | 2 studies · 37 participants | Low |
Early administration of aminophylline: return of spontaneous circulation Aminophylline vs placebo | OR 1.61 [0.38, 6.77] | 2 studies · 37 participants | Low |
Aminophylline compared to placebo for bradyasystolic cardiac arrest in adults
Population: participants with bradyasystolic cardiac arrest in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Survival to hospital discharge Aminophylline vs placebo | OR 0.58 [0.12, 2.74] | 5 studies · 1254 participants | Moderate Downgraded: risk of bias, imprecision |
Return of spontaneous circulation Aminophylline vs placebo | OR 1.15 [0.89, 1.49] | 5 studies · 1254 participants | High |
Survival to admission Aminophylline vs placebo | OR 0.92 [0.61, 1.39] | 4 studies · 1232 participants | Moderate |
Early administration of aminophylline: survival to hospital discharge Aminophylline vs placebo | no estimate extracted | 2 studies · 37 participants | Low |
Early administration of aminophylline: survival to hospital admission Aminophylline vs placebo | OR 0.22 [0.02, 2.36] | 2 studies · 37 participants | Low |
Early administration of aminophylline: return of spontaneous circulation Aminophylline vs placebo | OR 1.61 [0.38, 6.77] | 2 studies · 37 participants | Low |