Question · asked by 1 review
Orthodontic adhesives containing bioactive glass (BAG) particles/nanoparticles (including Ag-, Zn-, fluoride-, or Ga-doped BAG) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control: Enamel remineralization / anti-demineralization extent
- Population
- Human enamel specimens around orthodontic brackets (in vitro)
- Intervention
- Orthodontic adhesives containing bioactive glass (BAG) particles/nanoparticles (including Ag-, Zn-, fluoride-, or Ga-doped BAG)
- Comparison
- Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control
- Outcome
- Enamel remineralization / anti-demineralization extent
In vitro, most bioactive glass-containing orthodontic adhesives (9 of 13 studies) showed significant enamel remineralization/anti-demineralization versus control, but the evidence is weak (predominantly high risk of bias, methodological heterogeneity, no meta-analysis; ungraded).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Orthodontic adhesives containing bioactive glass (BAG) particles/nanoparticles (including Ag-, Zn-, fluoride-, or Ga-doped BAG) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control Enamel remineralization / anti-demineralization extent · Human enamel specimens around orthodontic brackets (in vitro) · pH cycling 14 days to 6 months (majority 14 days), In vitro (laboratory), Overall In vitro, most bioactive glass-containing orthodontic adhesives (9 of 13 studies) showed significant enamel remineralization/anti-demineralization versus control, but the evidence is weak (predominantly high risk of bias, methodological heterogeneity, no meta-analysis; ungraded). Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic… (2024) All outcomes | Out of 13 studies that evaluated bioactive glass particles/nanoparticles, 9 reported definitive statistically significant remineralization potential compared to control orthodontic adhesives [17, 21-24, 26-28, 31]; one… | 13 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic brackets: a systematic review… 2024 All outcomes | 2005 to 2024 (search coverage; exact search date not reported) | 25 | Low / Low |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Investigation of mechanical properties, remineralization, antibacterial effect, and cellular toxicity of composite orthodontic adhesive… · 2024 · included by 1 of these review
- Enhanced antimicrobial and remineralizing properties of self-adhesive orthodontic resin containing mesoporous bioactive glass and… · 2022 · included by 1 of these review
- Anti-Microbial and Remineralizing Properties of Self-Adhesive Orthodontic Resin Containing Mesoporous Bioactive Glass. · 2021 · included by 1 of these review
- Enamel Surface Remineralization Effect by Fluorinated Graphite and Bioactive Glass-Containing Orthodontic Bonding Resin. · 2019 · included by 1 of these review
- Fluorinated Bioactive Glass Nanoparticles: Enamel Demineralization Prevention and Antibacterial Effect of Orthodontic Bonding Resin. · 2019 · included by 1 of these review
- Effect of addition of bioactive glass to resin modified glass ionomer cement on enamel demineralization under orthodontic brackets. · 2019 · included by 1 of these review
- Antibacterial and remineralization effects of orthodontic bonding agents containing bioactive glass. · 2018 · included by 1 of these review
- Remineralization Property of an Orthodontic Primer Containing a Bioactive Glass with Silver and Zinc. · 2017 · included by 1 of these review
- Inhibition of enamel demineralization and bond-strength properties of bioactive glass containing 4-META/MMA-TBB-based resin adhesive. · 2015 · included by 1 of these review
- A novel biomimetic orthodontic bonding agent helps prevent white spot lesions adjacent to brackets. · 2013 · included by 1 of these review
- Firoz 2019 · included by 1 of these review
- Parihar 2024 · included by 1 of these review
- Song 2019 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.