Surgically induced or chronic acid gastroesophageal reflux (experimental) vs Non-reflux control animals: Dental erosion, alveolar bone destruction and oral/pharyngeal lesions
In experimental rat models, induced gastroesophageal reflux caused dental erosion, alveolar bone destruction and oral lesions compared with controls, supporting biological plausibility; evidence is ungraded animal research.
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Surgically induced or chronic acid gastroesophageal reflux (experimental) vs Non-reflux control animals Dental erosion, alveolar bone destruction and oral/pharyngeal lesions · Rat models with surgically induced or chronic acid gastroesophageal reflux · Experimental animal (rat) models In experimental rat models, induced gastroesophageal reflux caused dental erosion, alveolar bone destruction and oral lesions compared with controls, supporting biological plausibility; evidence is ungraded animal research. Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) All outcomes | Two rat-model studies found significantly higher rates of dental erosion, alveolar bone destruction and osteomyelitis (Higo) and shorter molar crown heights with dentin exposure, inflammatory infiltration and fibrosis… | 2 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. 2020 All outcomes | January 1990 to December 2019 (publication period searched) | 24 | Not applicable |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Dental and oropharyngeal lesions in rats with chronic acid reflux esophagitis · 2018 · included by 1 of these review
- An animal model of intrinsic dental erosion caused by gastro‐oesophageal reflux disease · 2009 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.