Longer vs shorter duration of combination nicotine replacement therapy: SAEs
It is very uncertain whether longer changes overall SAEs ‐ 26 weeks versus 8 weeks compared with shorter duration of combination nicotine replacement therapy (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Longer vs shorter duration of combination nicotine replacement therapy Overall SAEs ‐ 26 weeks versus 8 weeks · people who smoke It is very uncertain whether longer changes overall SAEs ‐ 26 weeks versus 8 weeks compared with shorter duration of combination nicotine replacement therapy (very low certainty). Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (2023) · Cochrane Headline outcomes only | RR 1.63 [0.6, 4.42] | 1 study · 544 participants | Very low |
Longer vs shorter duration of combination nicotine replacement therapy Overall SAEs ‐ 16 weeks versus 8 weeks · people who smoke Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (2023) · Cochrane Headline outcomes only | no estimate extracted | 1 study · 637 participants | Very low |
Longer vs shorter duration of combination nicotine replacement therapy Overall SAEs ‐ 6 weeks versus 2 weeks · people who smoke Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (2023) · Cochrane Headline outcomes only | no estimate extracted | 1 study · 987 participants | Very low |
Longer vs shorter duration of combination NRT Overall SAEs ‐ 26 weeks versus 8 weeks · People who smoke It is very uncertain whether longer changes overall SAEs ‐ 26 weeks versus 8 weeks compared with shorter duration of combination NRT (very low certainty). Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (2019) · Cochrane Headline outcomes onlyearlier version CD013308, superseded | RR 1.63 [0.6, 4.42] | 1 study · 544 participants | Very low |
Longer vs shorter duration of combination NRT Overall SAEs ‐ 16 weeks versus 8 weeks · People who smoke Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (2019) · Cochrane Headline outcomes onlyearlier version CD013308, superseded | no estimate extracted | 1 study · 637 participants | Very low |
Longer vs shorter duration of combination NRT Overall SAEs ‐ 6 weeks versus 2 weeks · People who smoke Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (2019) · Cochrane Headline outcomes onlyearlier version CD013308, superseded | no estimate extracted | 1 study · 987 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.