Heparin vs normal saline solution locking: Haemorrhage
Heparin showed no clear difference in haemorrhage at any site compared with normal saline solution locking (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Heparin vs normal saline solution locking Haemorrhage at any site · adults with central venous catheters Heparin showed no clear difference in haemorrhage at any site compared with normal saline solution locking (moderate certainty). Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults (2018) · Cochrane Headline outcomes onlyearlier version CD008462.PUB3, superseded | RR 1.32 [0.57, 3.07] | 4 studies · 1245 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults 2022 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.