Cochrane · systematic review · CD008462
Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults
López-Briz, E, Ruiz Garcia, V, Cabello, JB, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 66.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyHeparin versus normal saline solution locking for prevention of occlusion in central venous catheters in adults
Population: adults with CVCs
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Occlusion of CVC (combining participant, and catheter as unit of analysis) Blood withdrawing Heparin vs normal saline solution locking | RR 0.7 [0.51, 0.95] | 10 studies · 1672 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Duration of catheter patency (days; combining participant and catheter as unit of analysis) Blood withdrawing Heparin vs normal saline solution locking | no estimate extracted | 6 studies · 1788 participants | Low Downgraded: risk of bias, imprecision |
CVC‐related bloodstream infections (positive microbiological culture, participant as unit of analysis) Heparin vs normal saline solution locking | RR 0.66 [0.08, 5.8] | 3 studies · 1127 participants | Very low Downgraded: imprecision, inconsistency |
Mortality Heparin vs normal saline solution locking | RR 0.76 [0.44, 1.31] | 3 studies · 1100 participants | Very low Downgraded: risk of bias, imprecision |
Haemorrhage from any site Heparin vs normal saline solution locking | RR 1.54 | 3 studies · 1197 participants | Very low Downgraded: risk of bias, imprecision |
Heparin‐induced thrombocytopaenia Heparin vs normal saline solution locking | RR 0.21 [0.01, 4.27] | 3 studies · 443 participants | Very low Downgraded: risk of bias, imprecision |
Heparin versus normal saline solution locking for prevention of occlusion in central venous catheters in adults
Population: adults with central venous catheters
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Occlusion of CVC (combining participant and catheter as unit of analysis) Blood withdrawing Heparin vs normal saline solution locking | RR 0.7 [0.51, 0.95] | 10 studies · 1672 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Duration of catheter patency (days; combining participant and catheter as unit of analysis) Blood withdrawing Heparin vs normal saline solution locking | no estimate extracted | 6 studies · 1788 participants | Low Downgraded: risk of bias, imprecision |
CVC‐related sepsis (participant as unit of analysis) Positive microbiological culture Heparin vs normal saline solution locking | RR 0.74 [0.03, 19.54] | 2 studies · 1097 participants | Low |
Mortality Heparin vs normal saline solution locking | RR 0.76 [0.44, 1.31] | 3 studies · 1100 participants | Low Downgraded: risk of bias, imprecision |
Haemorrhage at any site Heparin vs normal saline solution locking | RR 1.32 [0.57, 3.07] | 4 studies · 1245 participants | Moderate Downgraded: imprecision |
Heparin‐induced thrombocytopaenia Heparin vs normal saline solution locking | RR 0.21 [0.01, 4.27] | 3 studies · 443 participants | Low Downgraded: imprecision |
Heparin for central venous catheters
Population: patients with central venous catheters
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Occlusion of CVC (unit of analysis—participant) Blood withdrawing | RR 0.21 | 2 studies · 150 participants | Very low Downgraded: risk of bias |
Duration of catheter patency (unit of analysis—participants) Blood withdrawing | no estimate extracted | 3 studies · 952 participants | Low Downgraded: risk of bias |
CVC‐related sepsis Positive microbiological culturef | RR 1.02 | 2 studies · 1097 participants | Moderate |
Mortality | RR 0.77 | 3 studies · 1100 participants | Moderate |
Haemorrhage at any site Oozing blood from catheterh | RR 1.37 | 3 studies · 1145 participants | Low Downgraded: risk of bias, imprecision |