Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs placebo or no treatment: Malignant transformation (oral cancer development)
It is very uncertain whether vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic… changes oral cancer development compared with placebo or no treatment (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs Placebo or no treatment Oral cancer development · People with a diagnosis of oral leukoplakia · 24 months (treatment lasted 12 months) It is very uncertain whether vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic… changes oral cancer development compared with placebo or no treatment (very low certainty). Interventions for treating oral leukoplakia to prevent oral cancer (2016) · Cochrane All outcomes | RR 0.11 [0.01, 2.05] | 1 study · 85 participants | Very low |
Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs Placebo or no treatment Malignant transformation (oral cancer development) · People with a diagnosis of oral leukoplakia Interventions for treating oral leukoplakia to prevent oral cancer (2006) · Cochrane All outcomesearlier version CD001829.PUB3, superseded | Malignant transformation (Comparison 1, Outcome 1.1), systemic vitamin A (Sankaranarayan 1997): not estimable; none of the treatments showed benefit vs placebo (2 studies, 172 participants). | 1 study | GRADE not reported |
Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs Placebo or no treatment Malignant transformation (oral cancer development) · People with a diagnosis of oral leukoplakia Interventions for treating oral leukoplakia to prevent oral cancer (2004) · Cochrane All outcomesearlier version CD001829.PUB2, superseded | Malignant transformation (Comparison 01, Outcome 01), systemic vitamin A (Sankaranarayan 1997): not estimable; none of the treatments showed benefit vs placebo (2 studies, 227 participants). | 1 study | GRADE not reported |
Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs Placebo or no treatment Malignant transformation (oral cancer development) · People with a diagnosis of oral leukoplakia Interventions for treating oral leukoplakia to prevent oral cancer (1999) · Cochrane All outcomesearlier version CD001829, superseded | Malignant transformation (Comparison 1, Outcome 1.1), systemic vitamin A subgroup (Sankaranarayan 1997): not estimable (RevMan RR 0.0 [0.0, 0.0], totals not selected); none of the treatments showed benefit vs placebo… | 1 study | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes | 2016-05 | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.