Hypertonic saline vs other intracranial pressure‐lowering agents: Glasgow Outcome Scale: poor outcome at 6 months
It is very uncertain whether hypertonic saline changes glasgow Outcome Scale: poor outcome at 6 months compared with other intracranial pressure‐lowering agents (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Hypertonic saline vs other intracranial pressure‐lowering agents Glasgow Outcome Scale: poor outcome at 6 months · people with acute traumatic brain injury It is very uncertain whether hypertonic saline changes glasgow Outcome Scale: poor outcome at 6 months compared with other intracranial pressure‐lowering agents (very low certainty). Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain… (2020) · Cochrane Headline outcomes only | RR 1.09 [0.82, 1.44] | 2 studies · 85 participants | Very low |
Hypertonic saline vs other intracranial pressure‐lowering agents Glasgow Outcome Scale: poor outcome at 6 months · people with acute traumatic brain injury It is very uncertain whether hypertonic saline changes glasgow Outcome Scale: poor outcome at 6 months compared with other intracranial pressure‐lowering agents (very low certainty). Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain… (2019) · Cochrane Headline outcomes onlyearlier version CD010904.PUB2, superseded | RR 1.09 [0.82, 1.44] | 2 studies · 85 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.