Question · asked by 1 review
Prophylactic antibiotics vs placebo: Preterm birth
- Population
- women in the second or third trimester of pregnancy before labour and delivery
- Intervention
- Prophylactic antibiotics
- Comparison
- placebo
- Outcome
- Preterm birth
Prophylactic antibiotics showed no clear difference in preterm delivery compared with placebo (low certainty).
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 0 · 0%High 1 · 50%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Prophylactic antibiotics vs placebo Preterm delivery · women in the second or third trimester of pregnancy before labour and delivery Prophylactic antibiotics showed no clear difference in preterm delivery compared with placebo (low certainty). Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and… (2015) · Cochrane Headline outcomes onlyearlier version CD002250.PUB2, superseded | RR 0.85 [0.64, 1.14] | 5 studies · 1480 participants | Low |
Prophylactic antibiotics vs placebo Preterm delivery · women in the second or third trimester of pregnancy before labour and delivery Prophylactic antibiotics showed no clear difference in preterm delivery compared with placebo (high certainty). Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and… (2015) · Cochrane Headline outcomes only | RR 0.88 [0.72, 1.09] | 6 studies · 3663 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.