10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) vs Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice): Arrest or reversal of noncavitated facial/lingual carious lesions
10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) may not differ from Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) for arrest or reversal of facial/lingual carious lesions (RR 1.28, 95% CI 0.97 to 1.68; low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) vs Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth) · 1 mo, Dental practice (professionally applied or prescribed nonrestorative caries treatments; parallel and split-mouth RCTs) 10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) may not differ from Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) for arrest or reversal of facial/lingual carious lesions (RR 1.28, 95% CI 0.97 to 1.68; low certainty). Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) All outcomes | RR 1.28 [0.97, 1.68] | 1 study · 45 participants | Low |
10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) vs Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth) · 3 mo, Dental practice (professionally applied or prescribed nonrestorative caries treatments; parallel and split-mouth RCTs) 10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) may be more effective than Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) for arrest or reversal of facial/lingual carious lesions (RR 1.23, 95% CI 1.06 to 1.42; low certainty). Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) All outcomes | RR 1.23 [1.06, 1.42] | 1 study · 45 participants | Low |
10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) vs Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth) · 2 mo, Dental practice (professionally applied or prescribed nonrestorative caries treatments; parallel and split-mouth RCTs) 10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) may not differ from Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) for arrest or reversal of facial/lingual carious lesions (RR 1.12, 95% CI 0.93 to 1.36; low certainty). Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) All outcomes | RR 1.12 [0.93, 1.36] | 1 study · 45 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. 2019 All outcomes | June 2017 | 54 | Critically Low / Critically Low |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.