Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs placebo or no treatment: Clinical resolution (oral lesion not completely resolved)
Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic… led to lower clinical resolution (oral lesion not completely resolved) compared with placebo or no treatment; GRADE not reported.
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs Placebo or no treatment Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia · 4 to 12 months Interventions for treating oral leukoplakia to prevent oral cancer (2016) · Cochrane All outcomes | SoF 1, Clinical resolution (not completely resolved) at 4 to 12 months: 'Studies could not be combined in meta-analysis. One study evaluated topical treatment and did not find evidence of benefit; 3 studies of systemic… | 4 studies | GRADE not reported |
Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs Placebo or no treatment Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic… led to lower clinical resolution (oral lesion not completely resolved) compared with placebo or no treatment; GRADE not reported. Interventions for treating oral leukoplakia to prevent oral cancer (2006) · Cochrane All outcomesearlier version CD001829.PUB3, superseded | RR 0.69 [0.50, 0.96] | 5 studies · 245 participants | GRADE not reported |
Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs Placebo or no treatment Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic… led to lower clinical resolution (oral lesion not completely resolved) compared with placebo or no treatment; GRADE not reported. Interventions for treating oral leukoplakia to prevent oral cancer (2004) · Cochrane All outcomesearlier version CD001829.PUB2, superseded | RR 0.69 [0.50, 0.96] | 5 studies · 245 participants | GRADE not reported |
Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs Placebo or no treatment Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic… showed no clear difference in clinical resolution (oral lesion not completely resolved) compared with placebo or no treatment; GRADE not reported. Interventions for treating oral leukoplakia to prevent oral cancer (1999) · Cochrane All outcomesearlier version CD001829, superseded | RR 0.72 [0.52, 1.01] | 4 studies · 224 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes | 2016-05 | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.