Trials
Trials and primary studies
Every primary study the non-Cochrane dental caries reviews include, resolved to one record per study so a trial included by several reviews is counted once. Most are randomized trials; aetiology and diagnostic reviews also include observational and accuracy studies.
Primary studies
5,083
2,113 PMID · 1,332 DOI · 1,638 author and year
In two or more reviews
277
overlap between reviews
Trial PICO extracted
0
extraction not run yet
Per-trial results
0
extraction not run yet
ReviewStudies included by Comparison of therapies of white spot lesions: a systematic review and network meta-analysis.. Show all studies
81 studies, most shared first
| Study | Year | Reviews | Outcome links | Trial PICO |
|---|---|---|---|---|
| Efficacy of 30% silver diamine fluoride compared to atraumatic restorative treatment on dentine caries arrestment in primary molars of preschool… Vollu et al, 2019 · Vollú Ana Lúcia, Rodrigues Gabriella Fernandes, et al. · Journal of dentistry PMID:31279925 | 2019 | 5 | 2 | not extracted yet |
| Caries arrest effectiveness of silver diamine fluoride compared to alternative restorative technique: randomized clinical trial. Abdellatif 2021 · Abdellatif H M, Ali A M, et al. · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry PMID:33387347 | 2021 | 4 | 1 | not extracted yet |
| A prospective, randomized placebo-controlled clinical trial on the effects of a fluoride rinse on white spot lesion development and bleeding in… van der Kaaij et al. 2015 · van der Kaaij Nicoline C W, van der Veen Monique H, et al. · European journal of oral sciences PMID:25913893 | 2015 | 4 | 1 | not extracted yet |
| Comparative evaluation of Icon® resin infiltration and Clinpro™ XT varnish on colour and fluorescence changes of white spot lesions: a randomized… Kannan et al. 2019 · Kannan Annapurna, Padmanabhan Sridevi · Progress in orthodontics PMID:31204437 | 2019 | 3 | none stated | not extracted yet |
| MI Varnish and MI Paste Plus in a caries prevention and remineralization study: a randomized controlled trial. Rechmann 2018 · Rechmann Peter, Bekmezian Sona, et al. · Clinical oral investigations PMID:29299732 | 2018 | 2 | none stated | not extracted yet |
| A 12-Week Assessment of the Treatment of White Spot Lesions with CPP-ACP Paste and/or Fluoride Varnish. Guclu 2016 · Güçlü Zeynep Aslı, Alaçam Alev, et al. · BioMed research international PMID:27843950 | 2016 | 2 | 2 | not extracted yet |
| Bailey et al. 2009 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Llena 2015 matched by author and year (probable) | NR | 2 | 1 | not extracted yet |
| Singh 2016 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Srisilapanan 2013 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Therapeutic effect of a novel bioactive glass-ceramics on early caries lesions: a single-center, randomized controlled clinical trial. Guo 2022 · Guo Xiangyu, Li Xue, et al. · Clinical oral investigations PMID:34036434 | 2022 | 1 | none stated | not extracted yet |
| Management of Post Orthodontic White Spot Lesions Using Resin Infiltration and CPP-ACP Materials- A Clinical Study. Simon 2022 · Simon Louis Solaman, Dash Jayanta Kumar, et al. · The Journal of clinical pediatric dentistry PMID:35311975 | 2022 | 1 | none stated | not extracted yet |
| Evaluation of fluoride varnish treatment of postorthodontic white spot lesions by visual inspection and laser fluorescence-A randomized controlled… Tomaževič 2022 · Tomaževič Tanja, Drevenšek Martina, et al. · Clinical and experimental dental research PMID:35510617 | 2022 | 1 | none stated | not extracted yet |
| Comparative evaluation of fluoride varnishes, self-assembling peptide-based remineralization agent, and enamel matrix protein derivative on… Lena Sezici 2021 · Lena Sezici Yağmur, Yetkiner Enver, et al. · Progress in orthodontics PMID:33491110 | 2021 | 1 | none stated | not extracted yet |
| Clinical Efficacy of Two Topical Agents for the Remineralization of Enamel White Spot Lesions in Primary Teeth. Esparza-Villalpando 2021 · Esparza-Villalpando Vicente, Fernandez-Hernandez Edy, et al. · Pediatric dentistry PMID:33892832 | 2021 | 1 | none stated | not extracted yet |
| Acceptability and effect of TiF4 on dental caries: a randomized controlled clinical trial. Souza 2021 · Souza Beatriz Martines de, Silva Mayara de Souza, et al. · Brazilian oral research PMID:34878076 | 2021 | 1 | none stated | not extracted yet |
| Randomised clinical trial investigating self-assembling peptide P11-4 in the treatment of early caries. Bröseler 2020 · Bröseler F, Tietmann C, et al. · Clinical oral investigations PMID:31037343 | 2020 | 1 | none stated | not extracted yet |
| Assessment of the effects of a fluoride dentifrice and GC Tooth Mousse on early caries lesions in primary anterior teeth using quantitative… Batayneh 2020 · Al-Batayneh O B, Bani Hmood E I, et al. · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry PMID:31134470 | 2020 | 1 | none stated | not extracted yet |
| Randomized Clinical Trial investigating Self-Assembling Peptide P11-4 for Treatment of Early Occlusal Caries. Doberdoli 2020 · Doberdoli Dafina, Bommer Claudine, et al. · Scientific reports PMID:32144336 | 2020 | 1 | none stated | not extracted yet |
| Effect of self-assembling peptide P11-4 on orthodontic treatment-induced carious lesions. Welk 2020 · Welk A, Ratzmann A, et al. · Scientific reports PMID:32321955 | 2020 | 1 | none stated | not extracted yet |
| Impact of self-assembling peptides in remineralisation of artificial early enamel lesions adjacent to orthodontic brackets. Jablonski 2020 · Jablonski-Momeni Anahita, Nothelfer R, et al. · Scientific reports PMID:32934335 | 2020 | 1 | none stated | not extracted yet |
| Efficacy of P11-4 for the treatment of initial buccal caries: a randomized clinical trial. Sedlakova Kondelova 2020 · Sedlakova Kondelova Paulina, Mannaa Alaa, et al. · Scientific reports PMID:33214593 | 2020 | 1 | none stated | not extracted yet |
| Effectiveness of Self-assembling Peptide P11-4 Compared to Tricalcium Phosphate Fluoride Varnish in Remineralization of White Spot Lesions: A… Kobeissi 2020 · Kobeissi Riham, Badr Sherine By, et al. · International journal of clinical pediatric dentistry PMID:33623327 | 2020 | 1 | none stated | not extracted yet |
| Comparative Evaluation of Resin Infiltration and Remineralisation of Noncavitated Smooth Surface Caries Lesions: 6-month Results. Gözetici 2019 · Gözetici Burcu, Öztürk-Bozkurt Funda, et al. · Oral health & preventive dentistry PMID:30874252 | 2019 | 1 | none stated | not extracted yet |
| Analysis of efficacy of the self-assembling peptide-based remineralization agent on artificial enamel lesions. Üstün 2019 · Üstün Nilüfer, Aktören Oya · Microscopy research and technique PMID:30884045 | 2019 | 1 | none stated | not extracted yet |
| Self-assembling Peptide P11-4 and Fluoride for Regenerating Enamel. Alkilzy 2018 · Alkilzy M, Tarabaih A, et al. · Journal of dental research PMID:28892645 | 2018 | 1 | none stated | not extracted yet |
| Long-term remineralizing effect of MI Paste Plus on regression of early caries after orthodontic fixed appliance treatment: a 12-month follow-up… Beerens 2018 · Beerens Moniek W, Ten Cate Jacob M, et al. · European journal of orthodontics PMID:29161371 | 2018 | 1 | none stated | not extracted yet |
| Effectiveness of MI Paste Plus and Remin Pro on remineralization and color improvement of postorthodontic white spot lesions. Heravi 2018 · Heravi Farzin, Ahrari Farzaneh, et al. · Dental research journal PMID:29576772 | 2018 | 1 | none stated | not extracted yet |
| The efficacy of resin infiltrate on the treatment of white spot lesions and developmental opacities. Ciftci 2018 · Ciftci Z Z, Hanimeli S, et al. · Nigerian journal of clinical practice PMID:30417842 | 2018 | 1 | none stated | not extracted yet |
| Resin infiltration technique and fluoride varnish on white spot lesions in children: Preliminary findings of a randomized clinical trial. Giray 2018 · Giray F Eren, Durhan M A, et al. · Nigerian journal of clinical practice PMID:30560818 | 2018 | 1 | none stated | not extracted yet |
| Treatment of post-orthodontic white spot lesions with CPP-ACP paste: A three year follow up study. Karabekiroğlu 2017 · Karabekiroğlu Said, Ünlü Nimet, et al. · Dental materials journal PMID:28835597 | 2017 | 1 | none stated | not extracted yet |
| Effects of toothpastes on white spot lesions around orthodontic brackets using quantitative light-induced fluorescence (QLF) : An in vitro study. Gokce 2017 · Gokce Gokcenur, Savas Selcuk, et al. · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie PMID:28929203 | 2017 | 1 | none stated | not extracted yet |
| Comparative assessment of fluoride varnish and fluoride film for remineralization of postorthodontic white spot lesions in adolescents and adults… He 2016 · He Tao, Li Xue, et al. · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics PMID:27241991 | 2016 | 1 | none stated | not extracted yet |
| Effect of Fluoride Varnish on Enamel Remineralization in Anterior Teeth with Molar Incisor Hypomineralization. Restrepo 2016 · Restrepo Manuel, Jeremias Fabiano, et al. · The Journal of clinical pediatric dentistry PMID:27472567 | 2016 | 1 | none stated | not extracted yet |
| Effects of various remineralizing agents on the outcome of post-orthodontic white spot lesions (WSLs): a clinical trial. Singh 2016 · Singh Sombir, Singh Satinder Pal, et al. · Progress in orthodontics PMID:27480987 | 2016 | 1 | none stated | not extracted yet |
| Randomised Clinical Trial on Resin Infiltration and Fluoride Varnish vs Fluoride Varnish Treatment Only of Smooth-surface Early Caries Lesions in… Turska-Szybka 2016 · Turska-Szybka Anna, Gozdowski Dariusz, et al. · Oral health & preventive dentistry PMID:27957559 | 2016 | 1 | none stated | not extracted yet |
| Efficacy of fluoride varnish and casein phosphopeptide-amorphous calcium phosphate for remineralization of primary teeth: a randomized clinical trial. Memarpour 2015 · Memarpour Mahtab, Fakhraei Ebrahim, et al. · Medical principles and practice : international journal of the Kuwait University, Health Science Centre PMID:25895964 | 2015 | 1 | none stated | not extracted yet |
| Effect of CPP-ACP Paste on Enamel Carious Lesion of Primary Upper Anterior Teeth Assessed by Quantitative Light-Induced Fluorescence: A One-Year… Sitthisettapong 2015 · Sitthisettapong Thanya, Doi Takashi, et al. · Caries research PMID:26228178 | 2015 | 1 | none stated | not extracted yet |
| CPP-ACP and CPP-ACFP versus fluoride varnish in remineralisation of early caries lesions. A prospective study. Llena 2015 · Llena C, Leyda A M, et al. · European journal of paediatric dentistry PMID:26418918 | 2015 | 1 | none stated | not extracted yet |
| Esthetic comparison of white-spot lesion treatment modalities using spectrometry and fluorescence. Yuan 2014 · Yuan He, Li Jiyao, et al. · The Angle orthodontist PMID:23984991 | 2014 | 1 | none stated | not extracted yet |
| The anti-caries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate assessed using Quantitative… Yin 2013 · Yin W, Hu D Y, et al. · Journal of dentistry PMID:23985435 | 2013 | 1 | none stated | not extracted yet |
| Comparison of the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the… Srisilapanan 2013 · Srisilapanan P, Korwanich N, et al. · Journal of dentistry PMID:23985436 | 2013 | 1 | none stated | not extracted yet |
| Comparative evaluation of remineralization potential of casein phosphopeptide-amorphous calcium phosphate and casein phosphopeptide-amorphous… Mehta 2013 · Mehta R, Nandlal B, et al. · Indian journal of dental research : official publication of Indian Society for Dental Research PMID:24552927 | 2013 | 1 | none stated | not extracted yet |
| Treatment of post-orthodontic white spot lesions with casein phosphopeptide-stabilised amorphous calcium phosphate. Bröchner 2011 · Bröchner Ann, Christensen Carsten, et al. · Clinical oral investigations PMID:20383545 | 2011 | 1 | none stated | not extracted yet |
| Effects of casein phosphopeptide amorphous calcium fluoride phosphate paste on white spot lesions and dental plaque after orthodontic treatment: a… Beerens 2010 · Beerens M W, van der Veen M H, et al. · European journal of oral sciences PMID:21083623 | 2010 | 1 | none stated | not extracted yet |
| Regression of post-orthodontic lesions by a remineralizing cream. Bailey 2009 · Bailey D L, Adams G G, et al. · Journal of dental research PMID:19887683 | 2009 | 1 | none stated | not extracted yet |
| Abdellatif 2021 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Alkilzy 2018 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Batayneh 2020 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Beerens 2010 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |