Non-Cochrane · prognostic · PM42892816
Incidence of Osteoradionecrosis and Dental Implant Survival in Patients With Irradiated Head and Neck Malignancies: A Systematic Review and Meta-Analysis.
Chatterjee Nirmalya, Ghosh Amrita, Swarnakar Arka, et al. · Cureus · 2026 · PubMed · doi:10.7759/cureus.116387
Findings
6 findings
| Population | ||||
|---|---|---|---|---|
| Patients with head and neck malignancies who received radiotherapy and underwent dental implant placement | Dental implant placement in irradiated jaw bone | None (single-arm pooled proportion) | Dental implant survival Follow-up >=18 months (up to 14 years) · Clinical (hospital/university) cohorts in Europe, USA, India and Korea · Jaw-specific data set (maxilla and mandible estimates combined) | Proportion 0.86 [0.78, 0.91] GRADE not reported 7 studies · 1433 participants |
| Patients with head and neck malignancies who received radiotherapy and dental implants | Dental implants in irradiated jaw | None | Implant survival All eligible implants | Proportion 0.87 [0.82, 0.91] Moderate Downgraded: inconsistency 11 studies · 2390 participants |
| Patients with head and neck malignancies who received radiotherapy and dental implants | Dental implants in irradiated jaw | None | Implant-level osteoradionecrosis incidence Implant level | Proportion 0.013 [0.002, 0.069] Low Downgraded: imprecision 3 studies |
| Patients with head and neck malignancies who received radiotherapy and dental implants | Dental implants in irradiated jaw | None | Patient-level osteoradionecrosis incidence Patient level | Proportion 0.039 [0.019, 0.076] Low Downgraded: imprecision 4 studies · 255 participants |
| Irradiated head and neck cancer patients with implants placed in the maxilla | Dental implant placement in irradiated jaw bone | None (single-arm pooled proportion) | Dental implant survival Follow-up >=18 months (up to 14 years) · Clinical (hospital/university) cohorts in Europe, USA, India and Korea · Jaw = Maxilla | Proportion 0.80 [0.64, 0.90] GRADE not reported 5 studies · 318 participants |
| Irradiated head and neck cancer patients with implants placed in the mandible | Dental implant placement in irradiated jaw bone | None (single-arm pooled proportion) | Dental implant survival Follow-up >=18 months (up to 14 years) · Clinical (hospital/university) cohorts in Europe, USA, India and Korea · Jaw = Mandible | Proportion 0.88 [0.80, 0.94] GRADE not reported 7 studies · 1115 participants |
Included primary studies 13
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Buddula 2011 Survival of dental implants in native and grafted bone in irradiated head and neck cancer patients: a retrospective analysis. PMID:22406706 | 2011 | 1 other review | not stated | not extracted yet |
| Laverty 2019 Outcomes of implant-based oral rehabilitation in head and neck oncology patients-a retrospective evaluation of a large, single regional… PMID:30834461 | 2019 | 1 other review | not stated | not extracted yet |
| Lee 2022 Risk factor analysis of dental implants in patients with irradiated head and neck cancer. PMID:35546491 | 2022 | 1 other review | not stated | not extracted yet |
| Mancha de la Plata 2012 Osseointegrated implant rehabilitation of irradiated oral cancer patients. PMID:21778009 | 2012 | 1 other review | not stated | not extracted yet |
| Pompa 2015 Survival of dental implants in patients with oral cancer treated by surgery and radiotherapy: a retrospective study. PMID:25599761 | 2015 | 1 other review | not stated | not extracted yet |
| Rana 2016 Assessment of the Survival of Dental Implants in Irradiated Jaws Following Treatment of Oral Cancer: A Retrospective Study. PMID:27843270 | 2016 | 1 other review | not stated | not extracted yet |
| Schiegnitz 2021 Clinical long-term and patient-reported outcomes of dental implants in oral cancer patients. PMID:34255187 | 2021 | 1 other review | not stated | not extracted yet |
| Schweyen 2022 Factors Influencing the Survival Rate of Teeth and Implants in Patients after Tumor Therapy to the Head and Neck Region-Part 2: Implant… PMID:36362546 | 2022 | 1 other review | not stated | not extracted yet |
| Visch 2002 A clinical evaluation of implants in irradiated oral cancer patients. PMID:12454102 | 2002 | 1 other review | not stated | not extracted yet |
| Desoutter 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Flores-Ruiz 2018 Implant survival in patients with oral cancer: A 5-year follow-up. PMID:29930780 | 2018 | this review only | not stated | not extracted yet |
| Korfage 2014 Overdentures on primary mandibular implants in patients with oral cancer: a follow-up study over 14 years. PMID:24951245 | 2014 | this review only | not stated | not extracted yet |
| Papi 2019 Crestal bone loss around dental implants placed in head and neck cancer patients treated with different radiotherapy techniques: a… PMID:30471831 | 2019 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Survival rate and risk factors of implants in patients with head and neck neoplasms: a systematic review and meta-analysis. (2026) | 9 | 0.11 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with head and neck malignancies who received radiotherapy and underwent dental implant placement; any RT type (conventional, cobalt, IMRT); primary or secondary implant placement | Irradiated head and neck cancer patients with dental implants (14 studies; 2002 to 2023) |
| Intervention | Exposure: dental implant placement in irradiated maxillary and/or mandibular bone | Dental implants in irradiated jaw bone, primary and secondary placement (n=14) |
| Comparison | None (single-arm meta-analysis of proportions) | None (single-arm) |
| Outcomes | Dental implant survival; incidence of ORN at patient level and at implant level | Implant survival (n=11 studies, 2,390 implants); patient-level ORN incidence (n=4 studies, 255 patients); implant-level ORN incidence (n=3 studies, 883 implants) |
| Study designs | Observational and interventional clinical studies in English (2000 to 2025); reviews, in vitro and animal studies excluded | Observational cohort studies, mostly retrospective (n=14) |
| Timing | Follow-up of at least 18 months | Follow-up about 2 years to up to 14 years |